Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 14286..14833 Replicon plasmid unnamed2
Accession NZ_CP032264
Organism Escherichia coli strain AR_0089

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag AM468_RS01060 Protein ID WP_000970007.1
Coordinates 14286..14567 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag AM468_RS01065 Protein ID WP_000079941.1
Coordinates 14564..14833 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM468_RS01020 9675..10559 - 885 Protein_11 hypothetical protein -
AM468_RS01030 10913..11515 + 603 WP_000517695.1 hypothetical protein -
AM468_RS01035 11571..12065 + 495 WP_001459505.1 hypothetical protein -
AM468_RS27360 12065..12331 + 267 WP_000955263.1 hypothetical protein -
AM468_RS01050 12808..13281 - 474 WP_001334658.1 hypothetical protein -
AM468_RS01055 13398..14246 - 849 WP_001057992.1 3'-5' exonuclease -
AM468_RS01060 14286..14567 - 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM468_RS01065 14564..14833 - 270 WP_000079941.1 hypothetical protein Antitoxin
AM468_RS01080 15742..16773 - 1032 WP_000907873.1 replication initiation protein -
AM468_RS01095 17746..18009 + 264 WP_001324596.1 ash family protein -
AM468_RS01100 17927..18214 + 288 WP_000074849.1 conjugal transfer protein TraA -
AM468_RS01110 18656..19189 + 534 WP_001303319.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 - 1..101614 101614
- flank IS/Tn blaCMY-2 - 6761..9492 2731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T111551 WP_000970007.1 NZ_CP032264:c14567-14286 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T111551 NZ_CP032264:c14567-14286 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT111551 WP_000079941.1 NZ_CP032264:c14833-14564 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT111551 NZ_CP032264:c14833-14564 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References