Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 717077..717912 Replicon chromosome
Accession NZ_CP032261
Organism Escherichia coli strain AR_0067

Toxin (Protein)


Gene name yeeV Uniprot ID S1PMM7
Locus tag AM446_RS05510 Protein ID WP_000854720.1
Coordinates 717077..717454 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3B7PDS8
Locus tag AM446_RS05515 Protein ID WP_001285612.1
Coordinates 717544..717912 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM446_RS05480 712325..713308 - 984 WP_001327875.1 KpsF/GutQ family sugar-phosphate isomerase -
AM446_RS28485 714119..714274 - 156 WP_000729639.1 hypothetical protein -
AM446_RS05485 714766..715092 - 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
AM446_RS05490 715089..715352 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
AM446_RS05495 715424..716290 - 867 WP_001290180.1 DUF4942 domain-containing protein -
AM446_RS05500 716383..716580 - 198 WP_000839238.1 DUF957 domain-containing protein -
AM446_RS05505 716592..717080 - 489 WP_000777672.1 hypothetical protein -
AM446_RS05510 717077..717454 - 378 WP_000854720.1 TA system toxin CbtA family protein Toxin
AM446_RS05515 717544..717912 - 369 WP_001285612.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM446_RS05520 717992..718213 - 222 WP_000692347.1 DUF987 domain-containing protein -
AM446_RS05525 718300..718776 - 477 WP_001186727.1 RadC family protein -
AM446_RS05530 718792..719277 - 486 WP_000849565.1 antirestriction protein -
AM446_RS05535 719332..720150 - 819 WP_047938428.1 DUF945 domain-containing protein -
AM446_RS05545 720250..720483 - 234 WP_024173997.1 DUF905 family protein -
AM446_RS05550 720569..720973 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
AM446_RS05555 720970..721317 + 348 WP_024173998.1 IS66 family insertion sequence element accessory protein TnpB -
AM446_RS05560 721366..722904 + 1539 WP_000099193.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF 696108..719277 23169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.02 Da        Isoelectric Point: 7.9087

>T111501 WP_000854720.1 NZ_CP032261:c717454-717077 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T111501 NZ_CP032261:c717454-717077 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13663.44 Da        Isoelectric Point: 6.0618

>AT111501 WP_001285612.1 NZ_CP032261:c717912-717544 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT111501 NZ_CP032261:c717912-717544 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAAT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FW05

Antitoxin

Source ID Structure
AlphaFold DB A0A3B7PDS8

References