Detailed information of TA system TA111486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 5997474..5997990
• Replicon: chromosome
• Accession: NZ_CP032257
• Organism: Pseudomonas aeruginosa strain AR_0111

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AM490_RS29740
• Protein ID: WP_071557699.1
• Coordinates: 5997709..5997990 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A482UCX2
• Locus tag: AM490_RS29735
• Protein ID: WP_033942931.1
• Coordinates: 5997474..5997719 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM490_RS29725	5993200..5996367	+	3168	WP_033942936.1	DEAD/DEAH box helicase	-
AM490_RS29730	5996491..5996949	+	459	Protein_5600	hypothetical protein	-
AM490_RS34365	5996867..5997304	-	438	WP_033942934.1	hypothetical protein	-
AM490_RS29735	5997474..5997719	+	246	WP_033942931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AM490_RS29740	5997709..5997990	+	282	WP_071557699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM490_RS29745	5998244..5998741	-	498	WP_033942928.1	DNA repair protein RadC	-
AM490_RS29750	5998752..5999663	-	912	WP_033942927.1	hypothetical protein	-
AM490_RS29755	5999756..6000760	-	1005	WP_033942926.1	YqaJ viral recombinase family protein	-
AM490_RS29760	6000835..6001803	-	969	WP_033942925.1	DUF932 domain-containing protein	-
AM490_RS29770	6002609..6002827	+	219	WP_071557701.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5975219..6019810	44591

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10721.55 Da
• Isoelectric Point: 10.6485

>T111486 WP_071557699.1 NZ_CP032257:5997709-5997990 [Pseudomonas aeruginosa]
MTYKLEFLPSALKEWEKLGHTVREQAKKKLRERLEAPKVQADALRDLPGHYKIKLRTAGYRLVYNVEDDRVVVIVVAVGK
RERSAAYKAAGKR

Nucleotide

• Length: 282 bp

>T111486 NZ_CP032257:5997709-5997990 [Pseudomonas aeruginosa]
ATGACCTATAAGCTCGAGTTCCTGCCCTCAGCGCTGAAGGAATGGGAGAAGCTGGGTCATACGGTGCGTGAGCAGGCAAA
GAAAAAACTGCGTGAGCGGCTGGAAGCACCAAAGGTACAGGCTGATGCCCTCAGGGATCTGCCTGGCCACTACAAGATCA
AGCTCCGAACAGCAGGCTATCGATTGGTCTATAATGTCGAGGATGATCGGGTGGTTGTGATTGTGGTCGCAGTGGGCAAG
CGTGAACGAAGTGCAGCTTACAAGGCAGCAGGTAAGCGTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8653.98 Da
• Isoelectric Point: 4.1469

>AT111486 WP_033942931.1 NZ_CP032257:5997474-5997719 [Pseudomonas aeruginosa]
MQSVLADVAVSVSELKKNPTGVMAGAGGMPVAVLNHNRVMGYMVPAELYEQMLDRLDDLDLIDVVNARSGEKGVPVNLDD
L

Nucleotide

• Length: 246 bp

>AT111486 NZ_CP032257:5997474-5997719 [Pseudomonas aeruginosa]
ATGCAGAGTGTTTTGGCTGACGTTGCCGTGAGCGTTTCTGAGCTGAAGAAAAACCCCACCGGTGTCATGGCTGGTGCGGG
TGGCATGCCGGTCGCAGTTCTCAATCATAACCGCGTGATGGGGTACATGGTGCCAGCCGAGCTGTACGAGCAGATGTTGG
ACCGTTTGGACGATCTGGATCTGATCGATGTCGTTAACGCGCGCTCCGGTGAGAAGGGTGTGCCGGTGAACCTGGATGAC
CTATAA

Structures

Antitoxin

• AlphaFold DB: A0A482UCX2