111483

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3442773..3443278 Replicon chromosome
Accession NZ_CP032257
Organism Pseudomonas aeruginosa strain AR_0111

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag AM490_RS17125 Protein ID WP_003083773.1
Coordinates 3442773..3443054 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag AM490_RS17130 Protein ID WP_003083775.1
Coordinates 3443051..3443278 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM490_RS17100 3438024..3439373 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
AM490_RS17105 3439422..3440108 + 687 WP_003083762.1 FadR family transcriptional regulator -
AM490_RS17110 3440209..3440943 + 735 WP_003117208.1 GntR family transcriptional regulator -
AM490_RS17115 3441147..3441533 + 387 WP_003083767.1 aegerolysin family protein -
AM490_RS17120 3441565..3442473 - 909 WP_003083769.1 LysR family transcriptional regulator -
AM490_RS17125 3442773..3443054 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
AM490_RS17130 3443051..3443278 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
AM490_RS17135 3443453..3444073 - 621 WP_003101226.1 hypothetical protein -
AM490_RS17140 3444174..3444674 + 501 WP_003162763.1 LEA type 2 family protein -
AM490_RS17145 3444747..3445088 + 342 WP_003101229.1 alkylphosphonate utilization protein -
AM490_RS17150 3445170..3446597 - 1428 WP_003083784.1 GABA permease -
AM490_RS17155 3446766..3448259 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T111483 WP_003083773.1 NZ_CP032257:c3443054-3442773 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T111483 NZ_CP032257:c3443054-3442773 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT111483 WP_003083775.1 NZ_CP032257:c3443278-3443051 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT111483 NZ_CP032257:c3443278-3443051 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References