Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4024707..4025232 Replicon chromosome
Accession NZ_CP032229
Organism Streptomyces seoulensis strain KCTC 9819

Toxin (Protein)


Gene name relE Uniprot ID A0A4V0ZZS9
Locus tag D0Z67_RS18840 Protein ID WP_031181009.1
Coordinates 4024707..4024970 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P6TYT9
Locus tag D0Z67_RS18845 Protein ID WP_031181010.1
Coordinates 4024963..4025232 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z67_RS18820 4019834..4020955 + 1122 WP_031181005.1 tyrosine-type recombinase/integrase -
D0Z67_RS18825 4020955..4021296 + 342 WP_031181006.1 helix-turn-helix transcriptional regulator -
D0Z67_RS18830 4021293..4023728 + 2436 WP_031181007.1 hypothetical protein -
D0Z67_RS18835 4023679..4024248 - 570 WP_031181008.1 GNAT family N-acetyltransferase -
D0Z67_RS18840 4024707..4024970 - 264 WP_031181009.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0Z67_RS18845 4024963..4025232 - 270 WP_031181010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0Z67_RS18850 4025379..4025675 - 297 WP_031181011.1 hypothetical protein -
D0Z67_RS18855 4025672..4026874 - 1203 WP_031181012.1 hypothetical protein -
D0Z67_RS18860 4027056..4028141 + 1086 WP_078873308.1 DUF4190 domain-containing protein -
D0Z67_RS18865 4028300..4029052 + 753 WP_031181014.1 GntR family transcriptional regulator -
D0Z67_RS18870 4029410..4029601 + 192 WP_031181015.1 SPOR domain-containing protein -
D0Z67_RS18875 4029642..4030052 + 411 WP_031181016.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9993.41 Da        Isoelectric Point: 8.5042

>T111427 WP_031181009.1 NZ_CP032229:c4024970-4024707 [Streptomyces seoulensis]
VSEYRTVFRPEAQAELRKIPRETALRILAKLTELESDPLGINTTALVSEPDRRRLRVGDYRVVYTIDNGELVIWVVHVGH
RSTVYST

Download         Length: 264 bp

>T111427 NZ_CP032229:c4024970-4024707 [Streptomyces seoulensis]
GTGAGTGAGTACCGAACCGTCTTCCGCCCCGAGGCACAGGCCGAGCTTCGAAAGATCCCGCGCGAGACGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAGCTGGAAAGCGACCCACTCGGTATCAACACCACCGCACTCGTGTCCGAGCCGGATCGTCGGC
GCCTACGGGTGGGCGACTACCGCGTCGTCTACACGATCGACAACGGAGAACTGGTGATCTGGGTCGTTCACGTGGGGCAC
CGGTCCACCGTTTACAGCACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10266.70 Da        Isoelectric Point: 4.6265

>AT111427 WP_031181010.1 NZ_CP032229:c4025232-4024963 [Streptomyces seoulensis]
MTQPLPIESIRDVRAHLAEVVERADRDDIPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMASSAPGIPIEDI
MRETLARSE

Download         Length: 270 bp

>AT111427 NZ_CP032229:c4025232-4024963 [Streptomyces seoulensis]
ATGACACAGCCGCTGCCCATAGAGAGCATCCGCGACGTGCGCGCGCATTTGGCGGAGGTCGTGGAGCGCGCCGACCGCGA
CGACATACCCACGGTGATCACGCGCCGCGGCAAGGAAGTCGCCGCTGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAATCGGATCATCGACGAGCGCATGGCCAGCTCCGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0ZZS9

Antitoxin

Source ID Structure
AlphaFold DB A0A4P6TYT9

References