Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 2437810..2438339 Replicon chromosome
Accession NZ_CP032229
Organism Streptomyces seoulensis strain KCTC 9819

Toxin (Protein)


Gene name relE Uniprot ID A0A4P6TTQ3
Locus tag D0Z67_RS11315 Protein ID WP_031184336.1
Coordinates 2437810..2438070 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V0ZZE8
Locus tag D0Z67_RS11320 Protein ID WP_031184335.1
Coordinates 2438067..2438339 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z67_RS11295 2434048..2435208 - 1161 WP_030814394.1 acyl-CoA dehydrogenase family protein -
D0Z67_RS11300 2435396..2436739 + 1344 WP_031184339.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
D0Z67_RS11305 2436848..2437354 - 507 WP_031184338.1 CGNR zinc finger domain-containing protein -
D0Z67_RS11310 2437437..2437796 + 360 WP_031184337.1 VOC family protein -
D0Z67_RS11315 2437810..2438070 - 261 WP_031184336.1 Txe/YoeB family addiction module toxin Toxin
D0Z67_RS11320 2438067..2438339 - 273 WP_031184335.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0Z67_RS11325 2438423..2438782 - 360 WP_031184334.1 MerR family transcriptional regulator -
D0Z67_RS11330 2438838..2439911 + 1074 WP_031184333.1 alkene reductase -
D0Z67_RS11335 2439908..2441086 - 1179 WP_031184332.1 dipeptidase -
D0Z67_RS11340 2441094..2441615 - 522 WP_078873779.1 5-(carboxyamino)imidazole ribonucleotide mutase -
D0Z67_RS11345 2441612..2442805 - 1194 WP_078873777.1 5-(carboxyamino)imidazole ribonucleotide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10256.70 Da        Isoelectric Point: 9.8599

>T111426 WP_031184336.1 NZ_CP032229:c2438070-2437810 [Streptomyces seoulensis]
VRSVHFDPDAWEDFLFRLAADRRMARRITRLIAEIQRDPFAGIGKPEPLKADLSGYWSRRIDDEHRLVYRADDKEVKILK
ARYHYG

Download         Length: 261 bp

>T111426 NZ_CP032229:c2438070-2437810 [Streptomyces seoulensis]
GTGAGGAGCGTCCACTTCGACCCCGACGCATGGGAGGACTTCCTCTTCCGGCTGGCCGCCGACCGTCGGATGGCGCGCCG
GATCACCCGGCTCATCGCTGAGATCCAGCGGGACCCCTTCGCCGGCATCGGCAAGCCGGAGCCGCTCAAGGCCGATCTGT
CCGGCTACTGGTCCCGTCGGATCGACGACGAGCACCGGCTGGTGTACCGGGCCGACGACAAGGAAGTGAAGATCCTCAAA
GCCCGGTACCACTACGGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10003.23 Da        Isoelectric Point: 4.8839

>AT111426 WP_031184335.1 NZ_CP032229:c2438339-2438067 [Streptomyces seoulensis]
MTISASEARRDLFPLIKRVNDDHEPVRVSSRGGDAVLMSAEDYESWQETVYLLRSPANARRLMEAVARDKAAAGAVTKSL
EELRQLAGEE

Download         Length: 273 bp

>AT111426 NZ_CP032229:c2438339-2438067 [Streptomyces seoulensis]
ATGACCATAAGCGCCAGTGAGGCACGTCGGGATCTGTTTCCCCTGATCAAGCGCGTCAACGACGATCACGAACCGGTCCG
TGTCAGCTCGCGTGGCGGAGATGCCGTCCTGATGTCGGCCGAGGACTACGAGTCCTGGCAGGAGACGGTGTATCTGCTGC
GTTCACCGGCGAACGCCCGGCGCCTGATGGAGGCGGTCGCCCGCGACAAGGCGGCGGCCGGCGCCGTCACCAAGTCGCTG
GAAGAACTGCGTCAGCTGGCGGGTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P6TTQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0ZZE8

References