Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 287718..288244 Replicon plasmid unnamed2
Accession NZ_CP032208
Organism Klebsiella pneumoniae strain AR_0109

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag AM488_RS28610 Protein ID WP_000323025.1
Coordinates 287957..288244 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag AM488_RS28605 Protein ID WP_004196370.1
Coordinates 287718..287957 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM488_RS28575 283055..283247 - 193 Protein_291 MFS transporter -
AM488_RS28580 283277..284254 + 978 WP_004196334.1 chromate resistance protein -
AM488_RS28585 284211..285587 + 1377 WP_004196363.1 chromate efflux transporter -
AM488_RS28590 285618..286307 - 690 WP_004196322.1 hypothetical protein -
AM488_RS28595 286321..287058 - 738 WP_008460272.1 HupE/UreJ family protein -
AM488_RS28600 287102..287467 - 366 WP_009651956.1 hypothetical protein -
AM488_RS28605 287718..287957 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AM488_RS28610 287957..288244 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
AM488_RS28615 288316..288474 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
AM488_RS32040 289080..290054 + 975 WP_004196336.1 hypothetical protein -
AM488_RS28625 290252..290629 - 378 WP_045289277.1 hypothetical protein -
AM488_RS28635 290956..291252 + 297 WP_094313394.1 hydrogenase expression/formation protein HypD -
AM488_RS28640 291321..292388 + 1068 WP_119183617.1 hypothetical protein -
AM488_RS28645 292544..292891 + 348 WP_042935949.1 hypothetical protein -
AM488_RS28650 292970..293203 + 234 WP_042935952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..310872 310872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T111399 WP_000323025.1 NZ_CP032208:287957-288244 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T111399 NZ_CP032208:287957-288244 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT111399 WP_004196370.1 NZ_CP032208:287718-287957 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT111399 NZ_CP032208:287718-287957 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References