Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2495916..2496432 Replicon chromosome
Accession NZ_CP032207
Organism Klebsiella pneumoniae strain AR_0109

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AM488_RS12805 Protein ID WP_002886902.1
Coordinates 2496148..2496432 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM488_RS12800 Protein ID WP_002886901.1
Coordinates 2495916..2496158 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM488_RS12785 2491945..2492685 + 741 WP_002886899.1 KDGP aldolase family protein -
AM488_RS12790 2492751..2493905 + 1155 WP_002886900.1 lactonase family protein -
AM488_RS12795 2493928..2495838 + 1911 WP_004152270.1 BglG family transcription antiterminator -
AM488_RS12800 2495916..2496158 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM488_RS12805 2496148..2496432 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM488_RS12810 2496436..2496900 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM488_RS12815 2497141..2499279 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
AM488_RS12820 2499636..2500379 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM488_RS30900 2500382..2500555 - 174 WP_002886906.1 hypothetical protein -
AM488_RS12825 2500640..2500948 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T111393 WP_002886902.1 NZ_CP032207:2496148-2496432 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T111393 NZ_CP032207:2496148-2496432 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT111393 WP_002886901.1 NZ_CP032207:2495916-2496158 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT111393 NZ_CP032207:2495916-2496158 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References