Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 8563..9110 Replicon plasmid unnamed
Accession NZ_CP032205
Organism Escherichia coli strain AR_0013

Toxin (Protein)


Gene name parE Uniprot ID A0A4Y1YQH8
Locus tag AM340_RS27980 Protein ID WP_012881118.1
Coordinates 8829..9110 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E2GHF7
Locus tag AM340_RS27975 Protein ID WP_012881119.1
Coordinates 8563..8832 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM340_RS27930 4192..4404 + 213 WP_001309245.1 ANR family transcriptional regulator -
AM340_RS27935 4649..5110 + 462 WP_001233838.1 thermonuclease family protein -
AM340_RS27940 5156..5365 + 210 WP_001298565.1 hemolysin expression modulator Hha -
AM340_RS27945 5403..5993 + 591 WP_000766807.1 DUF2726 domain-containing protein -
AM340_RS27950 6233..6487 + 255 WP_000083830.1 replication regulatory protein RepA -
AM340_RS27960 6725..6799 + 75 WP_001365705.1 RepA leader peptide Tap -
AM340_RS27965 6792..7649 + 858 WP_000130646.1 incFII family plasmid replication initiator RepA -
AM340_RS28755 8350..8508 + 159 WP_032142560.1 hypothetical protein -
AM340_RS27975 8563..8832 + 270 WP_012881119.1 ABC transporter ATPase Antitoxin
AM340_RS27980 8829..9110 + 282 WP_012881118.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM340_RS27985 9156..10004 + 849 WP_012881117.1 3'-5' exonuclease -
AM340_RS27990 10121..10603 + 483 WP_001311056.1 hypothetical protein -
AM340_RS27995 10638..11744 - 1107 Protein_16 maltoporin LamB -
AM340_RS28000 12196..13071 - 876 WP_001617865.1 class A extended-spectrum beta-lactamase CTX-M-14 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..70275 70275
- flank IS/Tn blaCTX-M-14 - 12196..14583 2387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10875.53 Da        Isoelectric Point: 8.4615

>T111377 WP_012881118.1 NZ_CP032205:8829-9110 [Escherichia coli]
MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T111377 NZ_CP032205:8829-9110 [Escherichia coli]
ATGATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTATATTGCGGAGCAGAACCTGAT
GGCTGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10206.54 Da        Isoelectric Point: 8.8735

>AT111377 WP_012881119.1 NZ_CP032205:8563-8832 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK

Download         Length: 270 bp

>AT111377 NZ_CP032205:8563-8832 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACTTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGATATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATAAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1YQH8

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y1YSD8

References