Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3984135..3984792 Replicon chromosome
Accession NZ_CP032185
Organism Klebsiella pneumoniae strain AR_0075

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM454_RS20090 Protein ID WP_002916310.1
Coordinates 3984135..3984545 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM454_RS20095 Protein ID WP_002916312.1
Coordinates 3984526..3984792 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM454_RS20070 3980135..3981868 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
AM454_RS20075 3981874..3982587 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM454_RS20080 3982610..3983506 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM454_RS20085 3983607..3984128 + 522 WP_004144730.1 flavodoxin FldB -
AM454_RS20090 3984135..3984545 - 411 WP_002916310.1 protein YgfX Toxin
AM454_RS20095 3984526..3984792 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM454_RS20100 3985038..3986021 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
AM454_RS20105 3986172..3986831 - 660 WP_002916317.1 hemolysin III family protein -
AM454_RS20110 3986995..3987306 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AM454_RS20115 3987356..3988084 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AM454_RS20120 3988203..3989636 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T111283 WP_002916310.1 NZ_CP032185:c3984545-3984135 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T111283 NZ_CP032185:c3984545-3984135 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT111283 WP_002916312.1 NZ_CP032185:c3984792-3984526 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT111283 NZ_CP032185:c3984792-3984526 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References