Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 58087..58613 Replicon plasmid unnamed2
Accession NZ_CP032169
Organism Klebsiella pneumoniae strain AR_0076

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag AM455_RS27425 Protein ID WP_000323025.1
Coordinates 58326..58613 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag AM455_RS27420 Protein ID WP_004196370.1
Coordinates 58087..58326 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM455_RS27390 53424..53616 - 193 Protein_62 MFS transporter -
AM455_RS27395 53646..54623 + 978 WP_004196334.1 chromate resistance protein -
AM455_RS27400 54580..55956 + 1377 Protein_64 chromate efflux transporter -
AM455_RS27405 55987..56676 - 690 WP_004196322.1 hypothetical protein -
AM455_RS27410 56690..57427 - 738 WP_008460272.1 HupE/UreJ family protein -
AM455_RS27415 57471..57836 - 366 WP_009651956.1 hypothetical protein -
AM455_RS27420 58087..58326 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AM455_RS27425 58326..58613 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
AM455_RS27430 58664..59698 - 1035 Protein_70 IS481 family transposase -
AM455_RS27435 59770..59928 + 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
AM455_RS27440 60626..60898 + 273 WP_032425552.1 hypothetical protein -
AM455_RS27445 60895..61245 + 351 WP_032425551.1 hypothetical protein -
AM455_RS27450 61260..61577 + 318 WP_015065519.1 hypothetical protein -
AM455_RS27460 62418..62774 + 357 WP_019706019.1 hypothetical protein -
AM455_RS27465 62835..62993 + 159 Protein_76 hypothetical protein -
AM455_RS27470 63232..63579 - 348 WP_023285905.1 DUF190 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..171589 171589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T111230 WP_000323025.1 NZ_CP032169:58326-58613 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T111230 NZ_CP032169:58326-58613 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT111230 WP_004196370.1 NZ_CP032169:58087-58326 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT111230 NZ_CP032169:58087-58326 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References