Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4194503..4195019 Replicon chromosome
Accession NZ_CP032167
Organism Klebsiella pneumoniae strain AR_0076

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag AM455_RS21280 Protein ID WP_004178374.1
Coordinates 4194503..4194787 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM455_RS21285 Protein ID WP_002886901.1
Coordinates 4194777..4195019 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM455_RS21260 4189899..4190207 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
AM455_RS29710 4190292..4190465 + 174 WP_069196977.1 hypothetical protein -
AM455_RS21265 4190468..4191211 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM455_RS21270 4191568..4193706 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
AM455_RS21275 4194035..4194499 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM455_RS21280 4194503..4194787 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM455_RS21285 4194777..4195019 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM455_RS21290 4195097..4197007 - 1911 WP_009486549.1 BglG family transcription antiterminator -
AM455_RS21295 4197030..4198184 - 1155 WP_023159544.1 lactonase family protein -
AM455_RS21300 4198251..4198991 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T111223 WP_004178374.1 NZ_CP032167:c4194787-4194503 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T111223 NZ_CP032167:c4194787-4194503 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT111223 WP_002886901.1 NZ_CP032167:c4195019-4194777 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT111223 NZ_CP032167:c4195019-4194777 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References