Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 403784..404441 Replicon chromosome
Accession NZ_CP032167
Organism Klebsiella pneumoniae strain AR_0076

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM455_RS02240 Protein ID WP_002916310.1
Coordinates 404031..404441 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM455_RS02235 Protein ID WP_002916312.1
Coordinates 403784..404050 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM455_RS02210 398940..400373 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
AM455_RS02215 400492..401220 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AM455_RS02220 401270..401581 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AM455_RS02225 401745..402404 + 660 WP_002916317.1 hemolysin III family protein -
AM455_RS02230 402555..403538 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AM455_RS02235 403784..404050 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM455_RS02240 404031..404441 + 411 WP_002916310.1 protein YgfX Toxin
AM455_RS02245 404448..404969 - 522 WP_004144730.1 flavodoxin FldB -
AM455_RS02250 405070..405966 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM455_RS02255 405989..406702 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM455_RS02260 406708..408441 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T111211 WP_002916310.1 NZ_CP032167:404031-404441 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T111211 NZ_CP032167:404031-404441 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT111211 WP_002916312.1 NZ_CP032167:403784-404050 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT111211 NZ_CP032167:403784-404050 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References