Detailed information of TA system TA111179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1992787..1993249
• Replicon: chromosome
• Accession: NZ_CP032159
• Organism: Staphylococcus warneri strain 22.1

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A2V3ZEQ2
• Locus tag: D3P10_RS09920
• Protein ID: WP_002465948.1
• Coordinates: 1993064..1993249 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A364UQZ8
• Locus tag: D3P10_RS09915
• Protein ID: WP_015365250.1
• Coordinates: 1992787..1993044 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3P10_RS09875	1987994..1988317	+	324	WP_015365247.1	thioredoxin family protein	-
D3P10_RS09880	1988429..1988968	-	540	WP_002465937.1	nitroreductase	-
D3P10_RS09885	1989046..1989762	-	717	WP_058709950.1	type I 3-dehydroquinate dehydratase	-
D3P10_RS09890	1989938..1990360	+	423	WP_002450862.1	organic hydroperoxide resistance protein	-
D3P10_RS09895	1990639..1991133	+	495	WP_002465942.1	GNAT family N-acetyltransferase	-
D3P10_RS09900	1991266..1991856	-	591	WP_058709949.1	histidine phosphatase family protein	-
D3P10_RS09905	1992065..1992298	+	234	WP_002450865.1	hypothetical protein	-
D3P10_RS09910	1992290..1992493	-	204	WP_015365249.1	sterile alpha motif-like domain-containing protein	-
D3P10_RS09915	1992787..1993044	+	258	WP_015365250.1	hypothetical protein	Antitoxin
D3P10_RS09920	1993064..1993249	+	186	WP_002465948.1	hypothetical protein	Toxin
D3P10_RS09925	1993350..1993931	+	582	WP_015365251.1	hypothetical protein	-
D3P10_RS09930	1993991..1994224	-	234	WP_002450870.1	hypothetical protein	-
D3P10_RS09935	1994489..1995241	+	753	WP_002465946.1	poly-gamma-glutamate hydrolase family protein	-
D3P10_RS09940	1995332..1995616	+	285	WP_002465939.1	hypothetical protein	-
D3P10_RS09945	1995694..1995909	+	216	WP_002465949.1	hypothetical protein	-
D3P10_RS09950	1996374..1996613	+	240	WP_002465943.1	hypothetical protein	-
D3P10_RS09955	1996842..1997075	+	234	WP_015365252.1	hypothetical protein	-
D3P10_RS09960	1997251..1997451	-	201	WP_002450876.1	cold-shock protein	-
D3P10_RS09965	1997772..1998137	-	366	WP_058709365.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-53)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6977.68 Da
• Isoelectric Point: 10.1605

>T111179 WP_002465948.1 NZ_CP032159:1993064-1993249 [Staphylococcus warneri]
MSLHFTILFWLSLIFIVAGAIILAIMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLLFGL

Nucleotide

• Length: 186 bp

>T111179 NZ_CP032159:1993064-1993249 [Staphylococcus warneri]
ATGAGCTTGCATTTTACAATTCTTTTTTGGCTTTCACTTATATTTATCGTAGCTGGTGCGATTATTCTAGCTATCATGCT
TAAAACTAAAAAAGAATCTAAGAAAGAATCTTATCTTGGTTTCACCATTGTATTCTTCATTTTTGGATTAGCTATGTTGA
TATATACATTATTATTCGGACTCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9908.17 Da
• Isoelectric Point: 4.5910

>AT111179 WP_015365250.1 NZ_CP032159:1992787-1993044 [Staphylococcus warneri]
MKLYIIHAINIILTILFIIFNVIITYNANLDDTLWLVPGLIVCGLIMMISFAIAITKKDLLSEVLFFINIILTLYYIYPI
FYDFL

Nucleotide

• Length: 258 bp

>AT111179 NZ_CP032159:1992787-1993044 [Staphylococcus warneri]
ATGAAACTATACATTATACATGCAATCAATATTATTTTAACGATATTATTTATTATTTTTAATGTAATTATTACTTATAA
TGCAAACCTAGACGATACCTTATGGTTAGTGCCTGGATTAATTGTATGCGGTTTGATTATGATGATTAGTTTTGCTATTG
CTATAACTAAAAAGGACTTGTTAAGTGAAGTTCTTTTCTTTATTAATATTATTCTTACACTGTACTACATTTATCCAATT
TTTTATGATTTTCTTTAA

Structures

Toxin

• AlphaFold DB: A0A2V3ZEQ2

Antitoxin

• AlphaFold DB: A0A364UQZ8