Detailed information of TA system TA111175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 985921..986727
• Replicon: chromosome
• Accession: NZ_CP032159
• Organism: Staphylococcus warneri strain 22.1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A364UNB4
• Locus tag: D3P10_RS05000
• Protein ID: WP_002466824.1
• Coordinates: 986548..986727 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: D3P10_RS04995
• Protein ID: WP_058710200.1
• Coordinates: 985921..986520 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3P10_RS04975	981723..983183	+	1461	WP_002466813.1	ABC transporter substrate-binding protein/permease	-
D3P10_RS04980	983176..983898	+	723	WP_002466809.1	amino acid ABC transporter ATP-binding protein	-
D3P10_RS04985	984140..985270	+	1131	WP_058710201.1	tRNA epoxyqueuosine(34) reductase QueG	-
D3P10_RS04990	985271..985741	+	471	WP_002466802.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
D3P10_RS04995	985921..986520	+	600	WP_058710200.1	hypothetical protein	Antitoxin
D3P10_RS05000	986548..986727	+	180	WP_002466824.1	hypothetical protein	Toxin
D3P10_RS05005	986870..987262	+	393	WP_015364871.1	hypothetical protein	-
D3P10_RS05010	987417..988802	+	1386	WP_058710199.1	class II fumarate hydratase	-
D3P10_RS05015	988861..989691	-	831	WP_002466807.1	RluA family pseudouridine synthase	-
D3P10_RS05020	989869..990981	+	1113	WP_058710198.1	GAF domain-containing sensor histidine kinase	-
D3P10_RS05025	991002..991625	+	624	WP_002466822.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6901.22 Da
• Isoelectric Point: 3.8441

>T111175 WP_002466824.1 NZ_CP032159:986548-986727 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Nucleotide

• Length: 180 bp

>T111175 NZ_CP032159:986548-986727 [Staphylococcus warneri]
ATGACTCAAAATAAAGATTCTAAAACAAATTACCACGAAGAAGAAAATGCAATGGTAACCGATTTAGATGATTTAAAAGA
CTTAGGAAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGAAAAATTAAATCAATCTCATGACTCAGATGTTCGTT
CTGATTTAGATCAAGATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22545.47 Da
• Isoelectric Point: 4.9641

>AT111175 WP_058710200.1 NZ_CP032159:985921-986520 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDVSGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT111175 NZ_CP032159:985921-986520 [Staphylococcus warneri]
ATGGCAATGAACTTTAAAGTATTTGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAATTTAA
TAACAACCCAATGACAATCGCAGGTGTTCATTTAACAAAAGATCATGCACCTGTATTAGATGAATTAAAAAAGAATGTTG
ATTTACATGCAGTTGATTTCAGTCAAATTAATATTTTAGATTATGATGAAAATCAATCATATTATGAAGCGTTAGGTGTA
CCACAAAGCCAAATTTATTCATTATCATACAACCAAGATGCTAATGACTTTATTTCAGATAAAATTAAAACAAAAGAAAA
TAAAGGTAAATTAGTCTTACAAGTTGTTTCAATTGATGTAAGTGGTAATTTAGATGTAAGTGTAAGACAAGGGTTATTAG
AAGCACGCGAAATATTCTTAGTTGTTACTGGTAGTAATAAACGTGAAGTAGTCGAAAAATTATATAACGAAAATGGAAAA
TCTAATTTTGAACCTGCAGACTTAAAAGCGCATCGTATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGACGTGAAAGAATACTTCACAGCTCGCTTTGCATAA

Structures

Toxin

• AlphaFold DB: A0A364UNB4