Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 836471..836981 Replicon chromosome
Accession NZ_CP032159
Organism Staphylococcus warneri strain 22.1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A364UNH7
Locus tag D3P10_RS04150 Protein ID WP_002466743.1
Coordinates 836775..836981 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag D3P10_RS04145 Protein ID WP_002466760.1
Coordinates 836471..836764 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3P10_RS04120 831597..832388 + 792 WP_058709701.1 hydroxyethylthiazole kinase -
D3P10_RS04125 832389..833030 + 642 WP_058709702.1 thiamine phosphate synthase -
D3P10_RS04130 833119..833988 + 870 WP_002466746.1 membrane protein insertase YidC -
D3P10_RS04135 834026..834670 - 645 WP_058709703.1 HD domain-containing protein -
D3P10_RS04140 834798..836282 - 1485 WP_058709704.1 cardiolipin synthase -
D3P10_RS04145 836471..836764 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
D3P10_RS04150 836775..836981 + 207 WP_002466743.1 heavy-metal-associated domain-containing protein Toxin
D3P10_RS04155 837120..837257 + 138 WP_002466770.1 hypothetical protein -
D3P10_RS04160 837397..838587 - 1191 WP_002466775.1 rod shape-determining protein RodA -
D3P10_RS04165 838945..840015 + 1071 WP_002466764.1 D-alanine--D-alanine ligase -
D3P10_RS04170 840031..841392 + 1362 WP_058709706.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.62 Da        Isoelectric Point: 3.8601

>T111173 WP_002466743.1 NZ_CP032159:836775-836981 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSEAIKNLLTEMIGVYQVDIDINSGNITIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

>T111173 NZ_CP032159:836775-836981 [Staphylococcus warneri]
GTGCAACAAAAAATTGTATATACTGCTGGAATAGAAACACAAGAACAATCTGAAGCTATAAAAAATCTTTTAACTGAAAT
GATAGGTGTATATCAAGTTGATATTGATATCAATTCTGGAAACATAACAATTGAATTTGAGACACCTGCGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGCTGGATATAAAGTGCTCTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT111173 WP_002466760.1 NZ_CP032159:836471-836764 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT111173 NZ_CP032159:836471-836764 [Staphylococcus warneri]
GTGACAGAACAAGATCATGCACATCACTCTGAACAAATTAAAGTCAATTTAAAATCGAGATTAAACCGAATTGAAGGTCA
AGTTAGAGCTATTAATCGAATGATAGAAGAGGATGTTTATTGCGATGATGTGTTAACTCAAATTAGAGCTACACGTTCTG
CATTAAATAGTGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATAGCAGATAAAGTAAATCAAGGTCATCAA
GAAGAAGCAATGGAGGAACTACTCGTTACGTTTCAAAAATTAATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNH7

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References