Detailed information of TA system TA111171

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 108418..108962
• Replicon: plasmid pELW1-1
• Accession: NZ_CP032156
• Organism: Mycobacterium sp. ELW1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: D3H54_RS30465
• Protein ID: WP_149383913.1
• Coordinates: 108418..108714 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: D3H54_RS30470
• Protein ID: WP_149383914.1
• Coordinates: 108711..108962 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3H54_RS30450	105100..105591	+	492	WP_149383910.1	transcriptional regulator	-
D3H54_RS30455	105643..106614	-	972	WP_149383911.1	DUF4226 domain-containing protein	-
D3H54_RS30460	106743..108371	+	1629	WP_149383912.1	serine/threonine protein kinase	-
D3H54_RS30465	108418..108714	-	297	WP_149383913.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D3H54_RS30470	108711..108962	-	252	WP_149383914.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
D3H54_RS30475	109463..110398	+	936	WP_149383915.1	hypothetical protein	-
D3H54_RS31395	110473..110619	+	147	WP_168215133.1	hypothetical protein	-
D3H54_RS30480	110943..111917	-	975	WP_149383916.1	hypothetical protein	-
D3H54_RS30485	111927..112121	-	195	WP_210419782.1	hypothetical protein	-
D3H54_RS30490	112172..113149	-	978	WP_149383917.1	IS481 family transposase	-
D3H54_RS30495	113241..113465	-	225	WP_210419783.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..221756	221756
	-	flank	IS/Tn	-	-	112172..113149	977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (3-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11487.95 Da
• Isoelectric Point: 6.6357

>T111171 WP_149383913.1 NZ_CP032156:c108714-108418 [Mycobacterium sp. ELW1]
VSRHVLSPAAQLDLEQIWDYTCERWGDDQAEKYVREIERAIQRVVQNPMIGRACDEVRAGYRRHAVGSHTLYYRLAGSDV
IDVVRILHQRMDVDRHLD

Nucleotide

• Length: 297 bp

>T111171 NZ_CP032156:c108714-108418 [Mycobacterium sp. ELW1]
GTGAGCCGGCATGTTCTGTCGCCCGCGGCCCAGCTGGACCTGGAACAGATCTGGGACTACACCTGCGAGCGTTGGGGTGA
TGATCAGGCAGAGAAGTACGTTCGGGAGATCGAGCGCGCGATCCAACGAGTGGTGCAGAATCCGATGATCGGTCGGGCCT
GCGATGAGGTGCGGGCCGGCTACCGAAGGCATGCGGTGGGTTCGCACACGCTGTACTACCGCCTTGCCGGCTCCGACGTC
ATCGACGTGGTTCGGATACTGCACCAACGGATGGACGTCGACCGCCACCTCGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9494.39 Da
• Isoelectric Point: 4.8723

>AT111171 WP_149383914.1 NZ_CP032156:c108962-108711 [Mycobacterium sp. ELW1]
VGKNTSFSLDEHYSAFIEQEVTSGRYRSASDVVRTALRLLEDRETRLRALRQALVDGERSGESTPFDFDEFVARKRTEDP
PSQ

Nucleotide

• Length: 252 bp

>AT111171 NZ_CP032156:c108962-108711 [Mycobacterium sp. ELW1]
GTGGGTAAGAACACCTCGTTCAGCCTCGATGAGCACTACAGCGCGTTTATCGAGCAAGAAGTCACCTCGGGCCGCTATCG
GTCGGCCAGCGACGTTGTGCGCACCGCTCTGCGGCTGCTCGAAGATCGCGAAACGCGGTTGCGCGCGCTGCGCCAGGCGC
TCGTCGACGGTGAACGCAGTGGGGAGTCAACGCCTTTTGATTTCGATGAGTTCGTTGCACGCAAGCGGACCGAGGACCCT
CCCTCACAGTGA