Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 3220585..3221193 Replicon chromosome
Accession NZ_CP032153
Organism Alcaligenes aquatilis strain QD168

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D3M96_RS14760 Protein ID WP_094197431.1
Coordinates 3220585..3220875 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag D3M96_RS14765 Protein ID WP_094197432.1
Coordinates 3220888..3221193 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3M96_RS14740 3215861..3216448 - 588 WP_094197428.1 XRE family transcriptional regulator -
D3M96_RS14745 3216588..3217550 + 963 WP_121739384.1 ornithine cyclodeaminase family protein -
D3M96_RS14750 3217587..3218879 + 1293 WP_094197429.1 MHS family MFS transporter -
D3M96_RS14755 3219147..3220535 + 1389 WP_162988264.1 ATP-dependent RNA helicase DbpA -
D3M96_RS14760 3220585..3220875 + 291 WP_094197431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D3M96_RS14765 3220888..3221193 + 306 WP_094197432.1 putative addiction module antidote protein Antitoxin
D3M96_RS14770 3221282..3222238 - 957 WP_108727827.1 LysR family transcriptional regulator -
D3M96_RS14775 3222623..3223981 + 1359 WP_094197434.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
D3M96_RS14780 3223978..3224526 + 549 WP_121739385.1 3-phenylpropionate/cinnamic acid dioxygenase subunit beta -
D3M96_RS14785 3224555..3224875 + 321 WP_094198412.1 bifunctional 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit -
D3M96_RS14790 3224872..3225687 + 816 WP_121739386.1 3-(cis-5,6-dihydroxycyclohexa-1, 3-dien-1-yl)propanoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10969.39 Da        Isoelectric Point: 7.2772

>T111167 WP_094197431.1 NZ_CP032153:3220585-3220875 [Alcaligenes aquatilis]
MKTIHTTDTFDHWFSGLRDKQAARRIQVRIDRAEDGNFGDCESVGEGVSEMRIHYGPGYRVYFVQRELEIVILLAGGNKS
TQNKDIKTALEIARQL

Download         Length: 291 bp

>T111167 NZ_CP032153:3220585-3220875 [Alcaligenes aquatilis]
ATGAAGACTATCCACACCACCGATACCTTCGATCACTGGTTTAGCGGTCTGCGCGACAAGCAAGCCGCCAGACGAATTCA
GGTTCGTATTGACCGAGCAGAAGATGGCAACTTTGGAGACTGTGAATCGGTCGGCGAAGGAGTTTCCGAGATGCGTATTC
ACTACGGACCTGGCTACCGTGTGTACTTTGTACAACGTGAACTGGAGATCGTGATCTTATTGGCGGGTGGCAATAAATCT
ACCCAGAATAAAGATATTAAAACTGCGCTGGAAATCGCGCGGCAACTATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10913.57 Da        Isoelectric Point: 6.7173

>AT111167 WP_094197432.1 NZ_CP032153:3220888-3221193 [Alcaligenes aquatilis]
MGTIKLRKWDSAEHLQTEEDMVLYLEACMEEAGNDAAFIAKALGNIARAKGMSQLAKETGLGRESLYKALSGEGNPSFGT
ILKVMHALGIKLQPQLAPHNS

Download         Length: 306 bp

>AT111167 NZ_CP032153:3220888-3221193 [Alcaligenes aquatilis]
ATGGGAACCATCAAATTACGCAAATGGGATAGTGCCGAACACCTCCAAACCGAGGAAGACATGGTGCTATACCTAGAAGC
CTGCATGGAGGAAGCTGGCAACGATGCCGCTTTCATTGCAAAAGCCTTGGGCAATATTGCTCGCGCCAAGGGCATGAGCC
AGTTGGCTAAAGAAACGGGCTTGGGACGTGAAAGCCTGTACAAAGCCCTGTCAGGCGAAGGCAATCCAAGCTTTGGCACC
ATTCTAAAAGTCATGCACGCTTTGGGAATCAAACTGCAACCACAGCTTGCTCCTCACAACTCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References