111159

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4795109..4795606 Replicon chromosome
Accession NZ_CP032145
Organism Escherichia coli strain 15.TR.026_OXA

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag D3F09_RS23315 Protein ID WP_001173343.1
Coordinates 4795433..4795606 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag D3F09_RS23310 Protein ID WP_000398619.1
Coordinates 4795109..4795405 (+) Length 99 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3F09_RS23290 4791839..4792558 - 720 WP_000611288.1 two-component system response regulator DcuR -
D3F09_RS23295 4792555..4794186 - 1632 WP_001216477.1 sensor histidine kinase -
D3F09_RS23300 4794366..4794596 + 231 WP_001550470.1 (4Fe-4S)-binding protein -
D3F09_RS23305 4794608..4794880 + 273 WP_000405647.1 N-acetyltransferase -
D3F09_RS23310 4795109..4795405 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
D3F09_RS23315 4795433..4795606 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
D3F09_RS23320 4795725..4797242 - 1518 WP_001550472.1 lysine--tRNA ligase -
D3F09_RS23325 4797479..4798936 - 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-57)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T111159 WP_001173343.1 NZ_CP032145:4795433-4795606 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T111159 NZ_CP032145:4795433-4795606 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT111159 WP_000398619.1 NZ_CP032145:4795109-4795405 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT111159 NZ_CP032145:4795109-4795405 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References