Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4223416..4224251 Replicon chromosome
Accession NZ_CP032145
Organism Escherichia coli strain 15.TR.026_OXA

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag D3F09_RS20710 Protein ID WP_001565141.1
Coordinates 4223874..4224251 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag D3F09_RS20705 Protein ID WP_001565140.1
Coordinates 4223416..4223784 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3F09_RS20685 4221164..4221982 + 819 WP_021536653.1 DUF945 domain-containing protein -
D3F09_RS20690 4222074..4222559 + 486 WP_001565139.1 antirestriction protein -
D3F09_RS20695 4222575..4223051 + 477 WP_001186724.1 RadC family protein -
D3F09_RS20700 4223120..4223341 + 222 WP_000692303.1 DUF987 domain-containing protein -
D3F09_RS20705 4223416..4223784 + 369 WP_001565140.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D3F09_RS20710 4223874..4224251 + 378 WP_001565141.1 TA system toxin CbtA family protein Toxin
D3F09_RS20715 4224248..4224736 + 489 WP_001565142.1 hypothetical protein -
D3F09_RS20720 4224748..4224945 + 198 WP_000839256.1 DUF957 domain-containing protein -
D3F09_RS20725 4225030..4225872 + 843 WP_001565143.1 DUF4942 domain-containing protein -
D3F09_RS26025 4226056..4226238 + 183 WP_177309578.1 hypothetical protein -
D3F09_RS20735 4226666..4227850 + 1185 WP_001172876.1 sugar efflux transporter -
D3F09_RS20740 4227961..4228884 + 924 WP_000535949.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14246.27 Da        Isoelectric Point: 7.2920

>T111157 WP_001565141.1 NZ_CP032145:4223874-4224251 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T111157 NZ_CP032145:4223874-4224251 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCATTTGTCCCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13604.41 Da        Isoelectric Point: 6.7389

>AT111157 WP_001565140.1 NZ_CP032145:4223416-4223784 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT111157 NZ_CP032145:4223416-4223784 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCAGATGCATACCACCTGGACCAGGCCTTTGCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References