Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4093468..4094080 Replicon chromosome
Accession NZ_CP032145
Organism Escherichia coli strain 15.TR.026_OXA

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag D3F09_RS20045 Protein ID WP_000833473.1
Coordinates 4093895..4094080 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag D3F09_RS20040 Protein ID WP_000499744.1
Coordinates 4093468..4093878 (-) Length 137 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3F09_RS20025 4088980..4089795 - 816 WP_000891823.1 AraC family transcriptional regulator -
D3F09_RS20030 4090021..4091421 + 1401 WP_000204811.1 MFS transporter -
D3F09_RS20035 4091432..4093396 + 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
D3F09_RS20040 4093468..4093878 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D3F09_RS20045 4093895..4094080 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
D3F09_RS20055 4094349..4095887 - 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
D3F09_RS20060 4096088..4097239 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T111156 WP_000833473.1 NZ_CP032145:c4094080-4093895 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T111156 NZ_CP032145:c4094080-4093895 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT111156 WP_000499744.1 NZ_CP032145:c4093878-4093468 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT111156 NZ_CP032145:c4093878-4093468 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9YXE2


Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References