111149

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2264886..2265717 Replicon chromosome
Accession NZ_CP032145
Organism Escherichia coli strain 15.TR.026_OXA

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag D3F09_RS11055 Protein ID WP_000854814.1
Coordinates 2265343..2265717 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag D3F09_RS11050 Protein ID WP_001285585.1
Coordinates 2264886..2265254 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3F09_RS11015 2261794..2262249 + 456 WP_000581504.1 hypothetical protein -
D3F09_RS11020 2262324..2262557 + 234 WP_001119729.1 DUF905 family protein -
D3F09_RS11030 2262657..2263475 + 819 WP_060626401.1 DUF945 domain-containing protein -
D3F09_RS11035 2263557..2264036 + 480 WP_000860087.1 antirestriction protein -
D3F09_RS11040 2264052..2264528 + 477 WP_039267628.1 RadC family protein -
D3F09_RS11045 2264591..2264812 + 222 WP_000692323.1 DUF987 domain-containing protein -
D3F09_RS11050 2264886..2265254 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
D3F09_RS11055 2265343..2265717 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
D3F09_RS11060 2265714..2265908 + 195 WP_000988600.1 hypothetical protein -
D3F09_RS11065 2265921..2266034 + 114 WP_001161660.1 DUF957 domain-containing protein -
D3F09_RS11070 2266323..2266451 - 129 Protein_2122 transposase domain-containing protein -
D3F09_RS11075 2266523..2266705 + 183 WP_001016348.1 hypothetical protein -
D3F09_RS11080 2266806..2267135 - 330 WP_000450409.1 DUF496 family protein -
D3F09_RS11085 2267307..2268365 - 1059 WP_001200891.1 FUSC family protein -
D3F09_RS11090 2268563..2269036 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
D3F09_RS11095 2269155..2270321 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T111149 WP_000854814.1 NZ_CP032145:2265343-2265717 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T111149 NZ_CP032145:2265343-2265717 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT111149 WP_001285585.1 NZ_CP032145:2264886-2265254 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT111149 NZ_CP032145:2264886-2265254 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References