Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT-BrnA
Location 120314..120902 Replicon chromosome
Accession NZ_CP032143
Organism Acinetobacter sp. WCHAc010052

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag CDG61_RS00965 Protein ID WP_087549720.1
Coordinates 120612..120902 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag CDG61_RS00960 Protein ID WP_087549719.1
Coordinates 120314..120628 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDG61_RS00940 116283..117437 - 1155 WP_087549716.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
CDG61_RS00945 117689..118315 - 627 WP_087513673.1 hypothetical protein -
CDG61_RS00950 118417..119412 - 996 WP_087549717.1 AraC family transcriptional regulator -
CDG61_RS00955 119943..120167 + 225 WP_087549718.1 hypothetical protein -
CDG61_RS00960 120314..120628 - 315 WP_087549719.1 BrnA antitoxin family protein Antitoxin
CDG61_RS00965 120612..120902 - 291 WP_087549720.1 BrnT family toxin Toxin
CDG61_RS00970 121132..121863 - 732 WP_147387762.1 hypothetical protein -
CDG61_RS00975 122092..123402 - 1311 WP_171405619.1 DUF445 family protein -
CDG61_RS00980 123430..123993 - 564 WP_087549723.1 hypothetical protein -
CDG61_RS00985 124247..124774 + 528 WP_087549724.1 dihydrofolate reductase family protein -
CDG61_RS00990 124855..125394 - 540 WP_087549725.1 DUF924 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-96)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11320.60 Da        Isoelectric Point: 5.9003

>T111125 WP_087549720.1 NZ_CP032143:c120902-120612 [Acinetobacter sp. WCHAc010052]
MEIEFSWDEHKAETNLKKHGVAFEDATLVFYDAYAVYKQDRFENGEYRWQAIGMVHGQAILLVAHTVQDHDGIDHIRIIS
ARQAVKKERNEYEQNR

Download         Length: 291 bp

>T111125 NZ_CP032143:c120902-120612 [Acinetobacter sp. WCHAc010052]
ATGGAAATTGAGTTTTCATGGGATGAGCATAAAGCCGAAACAAACCTCAAAAAGCATGGTGTGGCTTTTGAAGATGCAAC
TTTGGTTTTTTATGATGCTTATGCCGTATATAAACAGGATCGCTTTGAGAATGGTGAATATCGTTGGCAAGCGATAGGGA
TGGTACATGGTCAGGCAATCTTACTGGTTGCTCACACAGTACAAGACCATGATGGGATTGATCATATCCGTATCATTTCA
GCACGACAGGCAGTAAAAAAAGAGAGGAATGAATATGAGCAAAATCGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12110.96 Da        Isoelectric Point: 8.8990

>AT111125 WP_087549719.1 NZ_CP032143:c120628-120314 [Acinetobacter sp. WCHAc010052]
MSKIVKYKVDLNNPPVLPDEQKVRLEALAKRPDSEIDCSDIPELDENFWKNAVQNPFYKPTKQVTTVRIDADVMQWLKAQ
GKGYQTRMNKILRDAMLNELKNHP

Download         Length: 315 bp

>AT111125 NZ_CP032143:c120628-120314 [Acinetobacter sp. WCHAc010052]
ATGAGCAAAATCGTTAAATACAAAGTTGATTTGAACAATCCTCCAGTATTGCCTGATGAACAAAAAGTGAGACTGGAAGC
TTTAGCTAAACGTCCAGACAGCGAAATAGATTGTTCAGATATTCCTGAGCTTGATGAAAACTTCTGGAAAAATGCTGTTC
AAAACCCTTTTTATAAACCAACTAAGCAAGTGACAACTGTACGTATTGATGCGGACGTTATGCAGTGGTTAAAGGCTCAA
GGCAAAGGCTATCAGACACGTATGAATAAAATTCTGCGTGATGCTATGCTGAATGAATTAAAGAATCATCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References