Detailed information of TA system TA111113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 2473680..2474485
• Replicon: chromosome
• Accession: NZ_CP032125
• Organism: Profundibacter amoris strain BAR1

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: BAR1_RS12250
• Protein ID: WP_118943280.1
• Coordinates: 2473970..2474485 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: BAR1_RS12245
• Protein ID: WP_118943279.1
• Coordinates: 2473680..2473973 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAR1_RS12235	2472284..2472727	-	444	WP_118943277.1	C40 family peptidase	-
BAR1_RS12240	2472724..2473611	-	888	WP_118943278.1	DUF2163 domain-containing protein	-
BAR1_RS12245	2473680..2473973	+	294	WP_118943279.1	DUF1778 domain-containing protein	Antitoxin
BAR1_RS12250	2473970..2474485	+	516	WP_118943280.1	GNAT family N-acetyltransferase	Toxin
BAR1_RS12255	2474497..2475123	-	627	WP_118943281.1	DUF2460 domain-containing protein	-
BAR1_RS12260	2475124..2477256	-	2133	WP_118943282.1	phage tail tape measure protein	-
BAR1_RS12265	2477258..2477482	-	225	WP_162891845.1	hypothetical protein	-
BAR1_RS12270	2477479..2477916	-	438	WP_118943284.1	hypothetical protein	-
BAR1_RS12275	2477925..2478863	-	939	WP_118943285.1	hypothetical protein	-
BAR1_RS12280	2478919..2479350	-	432	WP_118943286.1	acyl-CoA transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2466007..2516385	50378

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (47-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (16-90)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 18409.15 Da
• Isoelectric Point: 7.8798

>T111113 WP_118943280.1 NZ_CP032125:2473970-2474485 [Profundibacter amoris]
MSAPKSPLRAPELLDDTHELDGFDCGAPSLDQWLKRRARGNQASGASRIYVVCRSNTVVGYYALAAGAVERDEAPSKVRR
NMPSRVPVIILGRLAVDNREQGNGIGAALLRDALLRVLNASQEIGAAAVLVHALNDRAKAFYLEHGFIESPIEPLVLMLR
IKDIAAALGEG

Nucleotide

• Length: 516 bp

>T111113 NZ_CP032125:2473970-2474485 [Profundibacter amoris]
ATGAGTGCGCCAAAATCTCCCCTGCGGGCACCGGAACTTCTCGACGACACTCATGAACTTGATGGGTTCGACTGCGGCGC
GCCAAGCCTTGACCAGTGGCTGAAACGCCGTGCAAGGGGCAATCAGGCATCGGGGGCTTCGCGGATCTATGTTGTTTGTC
GTAGTAACACCGTTGTCGGCTATTACGCTTTGGCTGCGGGTGCGGTCGAACGGGATGAGGCTCCGAGCAAGGTCCGGCGT
AATATGCCGTCCCGCGTTCCCGTCATCATCCTCGGTCGTTTGGCCGTGGACAATCGTGAACAGGGCAACGGGATCGGTGC
GGCGCTGCTGCGGGATGCGTTGCTGCGCGTTCTGAATGCATCGCAGGAAATCGGGGCGGCGGCGGTTCTGGTGCATGCGC
TAAATGACCGAGCCAAGGCGTTCTATCTGGAGCACGGGTTTATCGAGAGTCCGATAGAGCCGCTGGTTCTGATGCTGCGC
ATCAAGGATATCGCTGCTGCACTTGGCGAGGGTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10886.43 Da
• Isoelectric Point: 10.1685

>AT111113 WP_118943279.1 NZ_CP032125:2473680-2473973 [Profundibacter amoris]
MPVSHAATPAAHKSLINLRVTRRDRDLIDRAADALGKNRTEFMLEATRRAAEDALLDRSLFRLDPERFDAFQAALDAPAS
PSKTLRKLMATKAPWEE

Nucleotide

• Length: 294 bp

>AT111113 NZ_CP032125:2473680-2473973 [Profundibacter amoris]
ATGCCCGTATCCCACGCTGCCACCCCCGCCGCGCACAAATCGCTGATCAACCTGCGCGTCACCCGACGTGACCGGGATCT
TATCGATCGCGCGGCGGACGCTTTGGGCAAGAACCGCACCGAATTCATGCTCGAGGCCACACGGCGCGCGGCAGAAGACG
CCTTGCTTGACCGCAGCCTGTTCCGGCTGGACCCCGAGCGGTTTGATGCTTTCCAGGCCGCGCTTGATGCGCCCGCGAGC
CCCTCGAAAACCTTGCGTAAACTTATGGCAACCAAGGCTCCGTGGGAGGAATGA