Detailed information of TA system TA111108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1340107..1340643
• Replicon: chromosome
• Accession: NZ_CP032099
• Organism: Arcobacter skirrowii CCUG 10374

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A4V1LAW8
• Locus tag: ASKIR_RS07000
• Protein ID: WP_066161304.1
• Coordinates: 1340107..1340382 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q0UE78
• Locus tag: ASKIR_RS07005
• Protein ID: WP_066161303.1
• Coordinates: 1340383..1340643 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASKIR_RS06965	1335311..1335721	+	411	WP_066161311.1	SufE family protein	-
ASKIR_RS06970	1335744..1336094	+	351	WP_115588240.1	metal-sulfur cluster assembly factor	-
ASKIR_RS10295	1336271..1336453	-	183	WP_115588239.1	hypothetical protein	-
ASKIR_RS06980	1336485..1336820	-	336	WP_066351837.1	type II toxin-antitoxin system PemK/MazF family toxin	-
ASKIR_RS06985	1336811..1337026	-	216	WP_066351839.1	hypothetical protein	-
ASKIR_RS06990	1337154..1338365	-	1212	WP_115588238.1	major outer membrane protein	-
ASKIR_RS06995	1338630..1340081	+	1452	WP_066161305.1	acetyl-CoA carboxylase biotin carboxylase subunit	-
ASKIR_RS07000	1340107..1340382	-	276	WP_066161304.1	type II toxin-antitoxin system YafQ family toxin	Toxin
ASKIR_RS07005	1340383..1340643	-	261	WP_066161303.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ASKIR_RS07010	1340754..1341677	+	924	WP_066161302.1	AEC family transporter	-
ASKIR_RS07015	1341746..1341997	+	252	WP_066351848.1	hypothetical protein	-
ASKIR_RS07020	1341994..1342272	+	279	WP_066351850.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASKIR_RS07025	1342343..1343881	+	1539	WP_115588237.1	PAS domain-containing methyl-accepting chemotaxis protein	-
ASKIR_RS07030	1343890..1344447	-	558	WP_066158736.1	rhomboid family intramembrane serine protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (14-83)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10547.24 Da
• Isoelectric Point: 9.5188

>T111108 WP_066161304.1 NZ_CP032099:c1340382-1340107 [Arcobacter skirrowii CCUG 10374]
MLELEVHKTFTKDLKKAQLNSTNSSKLFLYISLLLNKKDLPKEAKNHSLSGEWEDTKEFHISGDLLVIYIINDTSLQLLR
IGTHSQLFKKF

Nucleotide

• Length: 276 bp

>T111108 NZ_CP032099:c1340382-1340107 [Arcobacter skirrowii CCUG 10374]
ATGCTTGAGTTAGAAGTTCACAAAACATTTACAAAAGATTTAAAAAAAGCCCAATTAAACTCAACAAACTCATCAAAACT
ATTTTTATATATATCACTACTTTTAAATAAAAAAGATTTACCAAAAGAGGCAAAAAATCACTCTTTATCAGGTGAATGGG
AAGATACAAAAGAGTTTCATATAAGTGGAGATTTACTTGTAATTTATATTATAAATGATACTAGCTTACAACTTTTAAGA
ATAGGAACTCACTCCCAACTTTTTAAAAAGTTTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9837.32 Da
• Isoelectric Point: 9.5404

>AT111108 WP_066161303.1 NZ_CP032099:c1340643-1340383 [Arcobacter skirrowii CCUG 10374]
MTTTSNKIRTNVYLDSTTKEKAQEIFKQYGLGLSEAFNIFLTQSVLQRGIPFEIKIPNDETLEAIKDARANKNMKKISLD
DLKKEL

Nucleotide

• Length: 261 bp

>AT111108 NZ_CP032099:c1340643-1340383 [Arcobacter skirrowii CCUG 10374]
ATGACTACAACTTCAAATAAAATACGAACAAATGTATATCTTGACTCAACAACAAAAGAAAAAGCTCAAGAGATTTTTAA
GCAGTATGGTTTAGGGTTAAGTGAAGCTTTTAATATATTTTTGACTCAAAGTGTTTTACAAAGAGGAATACCTTTTGAAA
TAAAGATTCCAAATGATGAAACTTTAGAAGCGATAAAAGATGCAAGAGCAAATAAAAATATGAAAAAAATTAGTTTAGAT
GATTTAAAAAAAGAGTTATAG

Structures

Toxin

• AlphaFold DB: A0A4V1LAW8

Antitoxin

• AlphaFold DB: A0A4Q0UE78