Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1854184..1854731 Replicon chromosome
Accession NZ_CP032093
Organism Vibrio alfacsensis strain CAIM 1831

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag D1115_RS08945 Protein ID WP_025548916.1
Coordinates 1854184..1854486 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR20
Locus tag D1115_RS08950 Protein ID WP_005398415.1
Coordinates 1854474..1854731 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1115_RS08890 1849720..1849810 - 91 Protein_1635 DUF3265 domain-containing protein -
D1115_RS08895 1849912..1850541 + 630 WP_128811072.1 hypothetical protein -
D1115_RS08900 1850457..1851122 + 666 WP_128811073.1 hypothetical protein -
D1115_RS23125 1851147..1851239 - 93 WP_206513183.1 DUF3265 domain-containing protein -
D1115_RS08905 1851267..1851554 - 288 WP_164837200.1 type II toxin-antitoxin system RelE/ParE family toxin -
D1115_RS08910 1851551..1851832 - 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
D1115_RS08915 1852033..1852569 - 537 WP_164837202.1 ATP-binding protein -
D1115_RS08920 1852599..1852691 - 93 WP_004748931.1 DUF3265 domain-containing protein -
D1115_RS08925 1852706..1853464 - 759 WP_128811075.1 hypothetical protein -
D1115_RS08930 1853492..1853632 - 141 WP_128811076.1 DUF3265 domain-containing protein -
D1115_RS08935 1853617..1853964 - 348 WP_017036770.1 DUF3024 domain-containing protein -
D1115_RS08940 1854056..1854148 - 93 WP_128811077.1 DUF3265 domain-containing protein -
D1115_RS08945 1854184..1854486 - 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1115_RS08950 1854474..1854731 - 258 WP_005398415.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D1115_RS08955 1854813..1854902 - 90 WP_072606010.1 DUF3265 domain-containing protein -
D1115_RS08960 1855419..1855510 - 92 Protein_1650 DUF3265 domain-containing protein -
D1115_RS08965 1855587..1855871 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
D1115_RS08970 1855868..1856146 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
D1115_RS08975 1856292..1856828 - 537 WP_206513184.1 hypothetical protein -
D1115_RS23270 1856835..1857068 - 234 WP_206513185.1 hypothetical protein -
D1115_RS23275 1857103..1857192 - 90 Protein_1655 DUF3265 domain-containing protein -
D1115_RS23130 1857321..1857545 + 225 WP_164837126.1 hypothetical protein -
D1115_RS08985 1857714..1857803 - 90 Protein_1657 DUF3265 domain-containing protein -
D1115_RS08990 1858323..1858433 - 111 WP_128812305.1 DUF3265 domain-containing protein -
D1115_RS08995 1858443..1858784 - 342 WP_206513186.1 N(4)-acetylcytidine aminohydrolase -
D1115_RS09000 1858955..1859254 - 300 WP_128811078.1 hypothetical protein -
D1115_RS09005 1859407..1859703 - 297 WP_128811079.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1786797..1876300 89503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T111100 WP_025548916.1 NZ_CP032093:c1854486-1854184 [Vibrio alfacsensis]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T111100 NZ_CP032093:c1854486-1854184 [Vibrio alfacsensis]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9578.04 Da        Isoelectric Point: 6.7269

>AT111100 WP_005398415.1 NZ_CP032093:c1854731-1854474 [Vibrio alfacsensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVASHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT111100 NZ_CP032093:c1854731-1854474 [Vibrio alfacsensis]
ATGAAAGTAGAACTAGTTACATCACTCAAACGCCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGAAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTGGCAAGTCATGATGAAGCTAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR20

References