Detailed information of TA system TA111099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1851267..1851832
• Replicon: chromosome
• Accession: NZ_CP032093
• Organism: Vibrio alfacsensis strain CAIM 1831

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D1115_RS08905
• Protein ID: WP_164837200.1
• Coordinates: 1851267..1851554 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: D1115_RS08910
• Protein ID: WP_000086647.1
• Coordinates: 1851551..1851832 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1115_RS08845	1846337..1846585	+	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
D1115_RS08850	1846575..1846865	+	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D1115_RS08855	1846884..1846973	-	90	WP_072615037.1	DUF3265 domain-containing protein	-
D1115_RS23120	1847243..1847410	-	168	WP_164837198.1	hypothetical protein	-
D1115_RS08860	1847438..1847548	-	111	WP_128812303.1	DUF3265 domain-containing protein	-
D1115_RS08865	1847545..1847931	-	387	WP_010648800.1	NUDIX hydrolase	-
D1115_RS08870	1848396..1848488	-	93	WP_206513182.1	DUF3265 domain-containing protein	-
D1115_RS08875	1848512..1849084	-	573	WP_128811071.1	hypothetical protein	-
D1115_RS08880	1849112..1849200	-	89	Protein_1634	DUF3265 domain-containing protein	-
D1115_RS08890	1849720..1849810	-	91	Protein_1635	DUF3265 domain-containing protein	-
D1115_RS08895	1849912..1850541	+	630	WP_128811072.1	hypothetical protein	-
D1115_RS08900	1850457..1851122	+	666	WP_128811073.1	hypothetical protein	-
D1115_RS23125	1851147..1851239	-	93	WP_206513183.1	DUF3265 domain-containing protein	-
D1115_RS08905	1851267..1851554	-	288	WP_164837200.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1115_RS08910	1851551..1851832	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1115_RS08915	1852033..1852569	-	537	WP_164837202.1	ATP-binding protein	-
D1115_RS08920	1852599..1852691	-	93	WP_004748931.1	DUF3265 domain-containing protein	-
D1115_RS08925	1852706..1853464	-	759	WP_128811075.1	hypothetical protein	-
D1115_RS08930	1853492..1853632	-	141	WP_128811076.1	DUF3265 domain-containing protein	-
D1115_RS08935	1853617..1853964	-	348	WP_017036770.1	DUF3024 domain-containing protein	-
D1115_RS08940	1854056..1854148	-	93	WP_128811077.1	DUF3265 domain-containing protein	-
D1115_RS08945	1854184..1854486	-	303	WP_025548916.1	type II toxin-antitoxin system RelE/ParE family toxin	-
D1115_RS08950	1854474..1854731	-	258	WP_005398415.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
D1115_RS08955	1854813..1854902	-	90	WP_072606010.1	DUF3265 domain-containing protein	-
D1115_RS08960	1855419..1855510	-	92	Protein_1650	DUF3265 domain-containing protein	-
D1115_RS08965	1855587..1855871	+	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
D1115_RS08970	1855868..1856146	+	279	WP_005398411.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
D1115_RS08975	1856292..1856828	-	537	WP_206513184.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1786797..1876300	89503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11013.67 Da
• Isoelectric Point: 5.1098

>T111099 WP_164837200.1 NZ_CP032093:c1851554-1851267 [Vibrio alfacsensis]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T111099 NZ_CP032093:c1851554-1851267 [Vibrio alfacsensis]
ATGAAAGTAGTCTGGTCTCCATTGGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
AGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATACCCCACACGAACTATCGCGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAGATTTTATCGGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT111099 WP_000086647.1 NZ_CP032093:c1851832-1851551 [Vibrio alfacsensis]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT111099 NZ_CP032093:c1851832-1851551 [Vibrio alfacsensis]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
TAATGAGACTCGTCGCCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0