Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1846337..1846865 Replicon chromosome
Accession NZ_CP032093
Organism Vibrio alfacsensis strain CAIM 1831

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag D1115_RS08850 Protein ID WP_005377002.1
Coordinates 1846575..1846865 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag D1115_RS08845 Protein ID WP_005377003.1
Coordinates 1846337..1846585 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1115_RS08800 1841780..1841911 - 132 WP_080338381.1 DUF3265 domain-containing protein -
D1115_RS23115 1841991..1842197 - 207 WP_164837125.1 hypothetical protein -
D1115_RS08810 1842400..1842492 - 93 WP_012841671.1 DUF3265 domain-containing protein -
D1115_RS08815 1842507..1842980 - 474 WP_128811070.1 GrpB family protein -
D1115_RS08820 1843126..1844760 - 1635 WP_206513181.1 AAA family ATPase -
D1115_RS08825 1844928..1845059 - 132 WP_010448899.1 DUF3265 domain-containing protein -
D1115_RS08835 1845549..1845641 - 93 WP_130273676.1 DUF3265 domain-containing protein -
D1115_RS23265 1846194..1846262 - 69 WP_074531725.1 DUF3265 domain-containing protein -
D1115_RS08845 1846337..1846585 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D1115_RS08850 1846575..1846865 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1115_RS08855 1846884..1846973 - 90 WP_072615037.1 DUF3265 domain-containing protein -
D1115_RS23120 1847243..1847410 - 168 WP_164837198.1 hypothetical protein -
D1115_RS08860 1847438..1847548 - 111 WP_128812303.1 DUF3265 domain-containing protein -
D1115_RS08865 1847545..1847931 - 387 WP_010648800.1 NUDIX hydrolase -
D1115_RS08870 1848396..1848488 - 93 WP_206513182.1 DUF3265 domain-containing protein -
D1115_RS08875 1848512..1849084 - 573 WP_128811071.1 hypothetical protein -
D1115_RS08880 1849112..1849200 - 89 Protein_1634 DUF3265 domain-containing protein -
D1115_RS08890 1849720..1849810 - 91 Protein_1635 DUF3265 domain-containing protein -
D1115_RS08895 1849912..1850541 + 630 WP_128811072.1 hypothetical protein -
D1115_RS08900 1850457..1851122 + 666 WP_128811073.1 hypothetical protein -
D1115_RS23125 1851147..1851239 - 93 WP_206513183.1 DUF3265 domain-containing protein -
D1115_RS08905 1851267..1851554 - 288 WP_164837200.1 type II toxin-antitoxin system RelE/ParE family toxin -
D1115_RS08910 1851551..1851832 - 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1786797..1876300 89503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T111098 WP_005377002.1 NZ_CP032093:1846575-1846865 [Vibrio alfacsensis]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T111098 NZ_CP032093:1846575-1846865 [Vibrio alfacsensis]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT111098 WP_005377003.1 NZ_CP032093:1846337-1846585 [Vibrio alfacsensis]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT111098 NZ_CP032093:1846337-1846585 [Vibrio alfacsensis]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References