Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1822036..1822802 Replicon chromosome
Accession NZ_CP032093
Organism Vibrio alfacsensis strain CAIM 1831

Toxin (Protein)


Gene name - Uniprot ID A0A432DAA5
Locus tag D1115_RS08620 Protein ID WP_017053840.1
Coordinates 1822305..1822802 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A347UQX1
Locus tag D1115_RS08615 Protein ID WP_017420534.1
Coordinates 1822036..1822308 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1115_RS23110 1817327..1817482 - 156 WP_164837196.1 hypothetical protein -
D1115_RS08550 1817643..1817963 - 321 WP_128811053.1 hypothetical protein -
D1115_RS08555 1818077..1818238 - 162 WP_128812291.1 DUF3265 domain-containing protein -
D1115_RS08560 1818288..1818503 - 216 WP_206513219.1 hypothetical protein -
D1115_RS08565 1818806..1819330 - 525 WP_038899652.1 hypothetical protein -
D1115_RS08570 1819363..1819455 - 93 WP_079858050.1 DUF3265 domain-containing protein -
D1115_RS08575 1819470..1820114 - 645 WP_061065168.1 peptidase E -
D1115_RS08580 1820156..1820287 - 132 Protein_1585 DUF3265 domain-containing protein -
D1115_RS08585 1820335..1820646 + 312 WP_164837124.1 hypothetical protein -
D1115_RS08590 1820773..1820889 - 117 WP_128812292.1 DUF3265 domain-containing protein -
D1115_RS08595 1820896..1821416 - 521 Protein_1588 GNAT family N-acetyltransferase -
D1115_RS08600 1821444..1821575 - 132 WP_005536196.1 DUF3265 domain-containing protein -
D1115_RS23255 1821834..1821926 - 93 WP_072612521.1 DUF3265 domain-containing protein -
D1115_RS08615 1822036..1822308 + 273 WP_017420534.1 DUF1778 domain-containing protein Antitoxin
D1115_RS08620 1822305..1822802 + 498 WP_017053840.1 GNAT family N-acetyltransferase Toxin
D1115_RS08625 1822836..1822928 - 93 WP_079399843.1 DUF3265 domain-containing protein -
D1115_RS08630 1823261..1823617 - 357 WP_128811056.1 hypothetical protein -
D1115_RS08635 1823889..1824134 + 246 WP_128811057.1 type II toxin-antitoxin system CcdA family antitoxin -
D1115_RS08640 1824134..1824451 + 318 WP_128811058.1 CcdB family protein -
D1115_RS08655 1825158..1825616 - 459 WP_128811060.1 GNAT family N-acetyltransferase -
D1115_RS08660 1825648..1825736 - 89 Protein_1598 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1827232..1827897 665
- inside Integron - - 1786797..1876300 89503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18458.12 Da        Isoelectric Point: 8.8085

>T111097 WP_017053840.1 NZ_CP032093:1822305-1822802 [Vibrio alfacsensis]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T111097 NZ_CP032093:1822305-1822802 [Vibrio alfacsensis]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTTATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGATTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9735.22 Da        Isoelectric Point: 8.5960

>AT111097 WP_017420534.1 NZ_CP032093:1822036-1822308 [Vibrio alfacsensis]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT111097 NZ_CP032093:1822036-1822308 [Vibrio alfacsensis]
ATGGCTACTACTTTGCCGCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGATCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A432DAA5

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQX1

References