Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1791727..1792276 Replicon chromosome
Accession NZ_CP032093
Organism Vibrio alfacsensis strain CAIM 1831

Toxin (Protein)


Gene name parE Uniprot ID A0A347UQT3
Locus tag D1115_RS08300 Protein ID WP_033006605.1
Coordinates 1791977..1792276 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A347UQT2
Locus tag D1115_RS08295 Protein ID WP_005442033.1
Coordinates 1791727..1791969 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1115_RS08240 1786797..1787129 - 333 WP_012600340.1 type II toxin-antitoxin system RelE/ParE family toxin -
D1115_RS08245 1787352..1787765 - 414 WP_128811030.1 VOC family protein -
D1115_RS08250 1787839..1787928 - 90 WP_128812283.1 DUF3265 domain-containing protein -
D1115_RS23105 1788057..1788299 + 243 WP_164837195.1 hypothetical protein -
D1115_RS08260 1788573..1788815 - 243 WP_128811031.1 hypothetical protein -
D1115_RS08265 1788913..1789179 - 267 WP_128811032.1 hypothetical protein -
D1115_RS08270 1789250..1789339 - 90 WP_075984317.1 DUF3265 domain-containing protein -
D1115_RS08275 1789457..1790421 + 965 Protein_1528 IS30 family transposase -
D1115_RS08285 1790890..1791486 - 597 WP_086716338.1 methyltransferase domain-containing protein -
D1115_RS08290 1791524..1791646 - 123 WP_080996720.1 DUF3265 domain-containing protein -
D1115_RS08295 1791727..1791969 + 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D1115_RS08300 1791977..1792276 + 300 WP_033006605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1115_RS08305 1792340..1792516 - 177 WP_128812286.1 DUF3265 domain-containing protein -
D1115_RS08310 1792547..1793514 + 968 Protein_1534 IS30 family transposase -
D1115_RS08315 1793540..1793927 - 388 Protein_1535 NUDIX hydrolase -
D1115_RS08325 1794619..1795778 + 1160 Protein_1536 IS3 family transposase -
D1115_RS08330 1796181..1796297 - 117 WP_081635026.1 DUF3265 domain-containing protein -
D1115_RS08335 1796294..1796909 - 616 Protein_1538 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1784678..1807250 22572
- inside IScluster/Tn - - 1784678..1795651 10973
- inside Integron - - 1786797..1876300 89503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11524.16 Da        Isoelectric Point: 9.6267

>T111096 WP_033006605.1 NZ_CP032093:1791977-1792276 [Vibrio alfacsensis]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEHD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T111096 NZ_CP032093:1791977-1792276 [Vibrio alfacsensis]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGGCTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCACCAAAGAACATGAC
TTTATCTTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.26 Da        Isoelectric Point: 5.6926

>AT111096 WP_005442033.1 NZ_CP032093:1791727-1791969 [Vibrio alfacsensis]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Download         Length: 243 bp

>AT111096 NZ_CP032093:1791727-1791969 [Vibrio alfacsensis]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGCGAAAGCTTTCTGAACTCGCTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UQT3

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQT2

References