Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 12926..13448 Replicon plasmid pL25922_2
Accession NZ_CP032088
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag D1792_RS25550 Protein ID WP_000220560.1
Coordinates 13167..13448 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag D1792_RS25545 Protein ID WP_000121743.1
Coordinates 12926..13177 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1792_RS25520 8086..9063 + 978 WP_001269914.1 hypothetical protein -
D1792_RS25525 9060..9485 - 426 WP_000202958.1 hypothetical protein -
D1792_RS25530 9556..9999 - 444 WP_001074379.1 hypothetical protein -
D1792_RS25535 10003..10845 - 843 WP_000435063.1 replication initiation protein -
D1792_RS25540 10866..11704 - 839 Protein_12 replication initiation protein -
D1792_RS25545 12926..13177 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
D1792_RS25550 13167..13448 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1792_RS25555 13594..13917 + 324 WP_001181903.1 hypothetical protein -
D1792_RS25560 13962..14207 + 246 WP_000356548.1 hypothetical protein -
D1792_RS25565 14197..14412 + 216 WP_001180116.1 hypothetical protein -
D1792_RS25570 14505..14834 + 330 WP_000866648.1 hypothetical protein -
D1792_RS25575 14876..15071 + 196 Protein_19 hypothetical protein -
D1792_RS25580 15141..15290 + 150 WP_000003880.1 hypothetical protein -
D1792_RS25585 15303..15575 + 273 WP_000160399.1 hypothetical protein -
D1792_RS25590 15806..16159 + 354 Protein_22 H-NS histone family protein -
D1792_RS25595 16235..16621 + 387 WP_000273881.1 hypothetical protein -
D1792_RS25600 16878..17342 + 465 WP_001443073.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..28563 28563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T111094 WP_000220560.1 NZ_CP032088:13167-13448 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T111094 NZ_CP032088:13167-13448 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATTA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT111094 WP_000121743.1 NZ_CP032088:12926-13177 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT111094 NZ_CP032088:12926-13177 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References