Detailed information of TA system TA111092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3182..3752
• Replicon: plasmid pL25922_1
• Accession: NZ_CP032087
• Organism: Escherichia coli strain ATCC 25922

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D1792_RS25290
• Protein ID: WP_207599262.1
• Coordinates: 3182..3511 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: D1792_RS25295
• Protein ID: WP_000121743.1
• Coordinates: 3501..3752 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1792_RS25255	65..450	-	386	Protein_1	hypothetical protein	-
D1792_RS25260	526..879	-	354	Protein_2	H-NS histone family protein	-
D1792_RS25265	1110..1379	-	270	Protein_3	hypothetical protein	-
D1792_RS25270	1613..1808	-	196	Protein_4	hypothetical protein	-
D1792_RS25275	1850..2170	-	321	WP_207599264.1	hypothetical protein	-
D1792_RS25280	2269..2484	-	216	WP_001180116.1	hypothetical protein	-
D1792_RS25285	2762..3085	-	324	WP_001181903.1	hypothetical protein	-
D1792_RS25290	3182..3511	-	330	WP_207599262.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
D1792_RS25295	3501..3752	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
D1792_RS25300	4973..5812	+	840	WP_001546350.1	replication initiation protein	-
D1792_RS25305	5833..6675	+	843	WP_000435063.1	replication initiation protein	-
D1792_RS25310	6679..7122	+	444	WP_001074379.1	hypothetical protein	-
D1792_RS25315	7193..7618	+	426	WP_000202958.1	hypothetical protein	-
D1792_RS25320	7615..8592	-	978	WP_001269914.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37009	37009

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12881.00 Da
• Isoelectric Point: 10.3533

>T111092 WP_207599262.1 NZ_CP032087:c3511-3182 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVIRSQICAKINHQMIDCLQSEREH

Nucleotide

• Length: 330 bp

>T111092 NZ_CP032087:c3511-3182 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATTA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTTATCAGATCGCAGATTTGCGCTAAGATTAATCATCAAATGATTGACTGTTTACAGTCAGAGCG
AGAGCATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9194.43 Da
• Isoelectric Point: 4.1683

>AT111092 WP_000121743.1 NZ_CP032087:c3752-3501 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Nucleotide

• Length: 252 bp

>AT111092 NZ_CP032087:c3752-3501 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S5I301