Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4060823..4061373 | Replicon | chromosome |
Accession | NZ_CP032085 | ||
Organism | Escherichia coli strain ATCC 25922 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | D1792_RS19495 | Protein ID | WP_001160966.1 |
Coordinates | 4061059..4061373 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | D1792_RS19490 | Protein ID | WP_000125566.1 |
Coordinates | 4060823..4061056 (+) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D1792_RS19465 | 4055896..4056183 | + | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
D1792_RS19470 | 4056242..4057573 | + | 1332 | WP_001183207.1 | MFS transporter | - |
D1792_RS19475 | 4057681..4058211 | + | 531 | WP_000600725.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
D1792_RS19480 | 4058204..4060066 | + | 1863 | WP_000377123.1 | glutathione-regulated potassium-efflux system protein KefC | - |
D1792_RS19485 | 4060258..4060737 | + | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
D1792_RS19490 | 4060823..4061056 | + | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
D1792_RS19495 | 4061059..4061373 | + | 315 | WP_001160966.1 | CcdB family protein | Toxin |
D1792_RS19500 | 4061370..4062218 | - | 849 | WP_000257182.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
D1792_RS19505 | 4062225..4062602 | - | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
D1792_RS19510 | 4062605..4063426 | - | 822 | WP_001065363.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
D1792_RS19515 | 4063423..4064412 | - | 990 | WP_000241229.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
D1792_RS19520 | 4064412..4065698 | - | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T111087 WP_001160966.1 NZ_CP032085:4061059-4061373 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T111087 NZ_CP032085:4061059-4061373 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT111087 WP_000125566.1 NZ_CP032085:4060823-4061056 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT111087 NZ_CP032085:4060823-4061056 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |