Detailed information of TA system TA111060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2637366..2638033
• Replicon: chromosome
• Accession: NZ_CP032084
• Organism: Achromobacter sp. B7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DVB37_RS11885
• Protein ID: WP_120155295.1
• Coordinates: 2637366..2637785 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2S5GS07
• Locus tag: DVB37_RS11890
• Protein ID: WP_046807503.1
• Coordinates: 2637782..2638033 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVB37_RS11855	2632606..2633565	-	960	WP_120155285.1	DMT family transporter	-
DVB37_RS11860	2633728..2634552	-	825	WP_120157464.1	AraC family transcriptional regulator	-
DVB37_RS11865	2634549..2634887	-	339	WP_120155287.1	hypothetical protein	-
DVB37_RS11870	2634835..2636109	-	1275	WP_120155290.1	RNA polymerase sigma factor	-
DVB37_RS11875	2636106..2636567	-	462	WP_120155292.1	VOC family protein	-
DVB37_RS11880	2636609..2637019	-	411	WP_104143811.1	YciI family protein	-
DVB37_RS11885	2637366..2637785	-	420	WP_120155295.1	type II toxin-antitoxin system VapC family toxin	Toxin
DVB37_RS11890	2637782..2638033	-	252	WP_046807503.1	Arc family DNA-binding protein	Antitoxin
DVB37_RS11895	2638130..2638483	-	354	WP_120155297.1	dehydrogenase	-
DVB37_RS11905	2638822..2639757	-	936	Protein_2324	OmpA family protein	-
DVB37_RS11910	2639754..2640644	-	891	WP_046807505.1	MotA/TolQ/ExbB proton channel family protein	-
DVB37_RS11915	2640932..2642695	+	1764	Protein_2326	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (11-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14590.70 Da
• Isoelectric Point: 5.0174

>T111060 WP_120155295.1 NZ_CP032084:c2637785-2637366 [Achromobacter sp. B7]
MILLDTNVISEPLRQAPSDAVIAWIDRQPLETLFLSAVTVAELRFGVACMAAGKRRNVLQDSLEQQVLALFAGRVLSFDT
AASQQYAALMARARASGQAIAAADGYIAATAAAHGMSVATRDVAPFTAAGASVIDPWQS

Nucleotide

• Length: 420 bp

>T111060 NZ_CP032084:c2637785-2637366 [Achromobacter sp. B7]
ATGATTCTGCTGGATACCAACGTCATCTCCGAGCCGCTGCGCCAGGCGCCATCCGATGCCGTCATTGCCTGGATCGACAG
GCAGCCGCTGGAAACCCTGTTTCTATCGGCGGTCACGGTTGCCGAATTGCGTTTTGGCGTGGCCTGCATGGCTGCCGGCA
AACGCCGCAACGTCTTGCAAGACAGCCTGGAGCAACAAGTGTTGGCGTTATTTGCCGGGCGCGTGCTGTCTTTCGACACC
GCCGCAAGCCAGCAATATGCGGCTTTAATGGCGCGTGCGCGGGCCTCGGGTCAGGCAATTGCCGCGGCGGATGGATACAT
CGCCGCCACCGCCGCTGCGCACGGCATGAGCGTCGCCACGCGGGACGTGGCGCCTTTTACGGCGGCGGGCGCTTCAGTGA
TCGATCCCTGGCAGTCGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9215.53 Da
• Isoelectric Point: 10.2879

>AT111060 WP_046807503.1 NZ_CP032084:c2638033-2637782 [Achromobacter sp. B7]
MPMLTVRNISDEVHRALRVRAAQHGRSTEAEVRAILEDAVKPEGRVKLGSLLARIGNQAKLTDQEAALFDQRDKTPAAPP
RFE

Nucleotide

• Length: 252 bp

>AT111060 NZ_CP032084:c2638033-2637782 [Achromobacter sp. B7]
ATGCCTATGTTGACTGTCAGGAACATCTCCGACGAAGTGCACCGCGCGCTGCGCGTGCGGGCGGCCCAGCATGGCCGCAG
CACCGAAGCCGAGGTGCGCGCCATTCTGGAAGATGCCGTCAAGCCTGAAGGGCGGGTCAAGCTGGGTTCGCTGCTTGCGC
GTATTGGCAACCAAGCCAAACTGACCGACCAGGAAGCCGCCCTGTTCGACCAACGCGACAAAACGCCTGCCGCGCCGCCG
AGGTTCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S5GS07