Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1204757..1205391 Replicon chromosome
Accession NZ_CP032084
Organism Achromobacter sp. B7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DVB37_RS05415 Protein ID WP_120157395.1
Coordinates 1205209..1205391 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DVB37_RS05410 Protein ID WP_104142930.1
Coordinates 1204757..1205149 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVB37_RS05390 1200146..1201669 - 1524 WP_120157394.1 sensor histidine kinase -
DVB37_RS05395 1201672..1202376 - 705 WP_120154189.1 response regulator transcription factor -
DVB37_RS05400 1202567..1203907 + 1341 WP_120154191.1 CitMHS family transporter -
DVB37_RS05405 1203944..1204684 + 741 WP_104142929.1 SDR family oxidoreductase -
DVB37_RS05410 1204757..1205149 - 393 WP_104142930.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DVB37_RS05415 1205209..1205391 - 183 WP_120157395.1 type II toxin-antitoxin system HicA family toxin Toxin
DVB37_RS05420 1205511..1205852 + 342 WP_046802511.1 hypothetical protein -
DVB37_RS05425 1205891..1206337 - 447 WP_104142933.1 hypothetical protein -
DVB37_RS05430 1206816..1207019 + 204 WP_006217928.1 cold-shock protein -
DVB37_RS05435 1207060..1207317 + 258 WP_046802513.1 hypothetical protein -
DVB37_RS05440 1207431..1208348 + 918 WP_120154193.1 DUF808 domain-containing protein -
DVB37_RS05445 1208649..1209518 + 870 WP_104142935.1 hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6745.01 Da        Isoelectric Point: 11.3078

>T111059 WP_120157395.1 NZ_CP032084:c1205391-1205209 [Achromobacter sp. B7]
MDSREIIRQLRLAGWVYRNARGLQHIYVHPPKPGHISVPHPKKDLGIGLVAKLLTQAGLK

Download         Length: 183 bp

>T111059 NZ_CP032084:c1205391-1205209 [Achromobacter sp. B7]
ATGGACAGCCGCGAAATCATCAGACAGCTCCGCCTGGCGGGTTGGGTCTACCGCAACGCGAGAGGCTTGCAACACATTTA
TGTCCACCCGCCAAAGCCCGGACATATCAGCGTGCCCCATCCGAAAAAGGATTTGGGAATCGGCTTGGTCGCCAAGCTGC
TGACGCAGGCAGGACTGAAGTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13776.57 Da        Isoelectric Point: 4.1961

>AT111059 WP_104142930.1 NZ_CP032084:c1205149-1204757 [Achromobacter sp. B7]
MKYPIAIEPGSDTQAWGVVVPDLPGCYSASDTGIDDAIENAKEAIALWIETALDTGAAVPPPGSIAAHQANPEFAGWVWA
IVDIDPAVMDDTIERVNITLPRRILARIDAKARAAGESRSGYIAQLALTH

Download         Length: 393 bp

>AT111059 NZ_CP032084:c1205149-1204757 [Achromobacter sp. B7]
ATGAAATACCCCATCGCCATAGAGCCCGGCAGCGACACGCAAGCGTGGGGCGTGGTCGTACCGGATCTGCCTGGCTGCTA
TTCCGCATCCGACACGGGCATTGACGATGCCATCGAAAATGCCAAAGAAGCGATAGCGCTCTGGATAGAAACAGCACTGG
ACACTGGCGCCGCCGTGCCACCGCCAGGAAGCATCGCGGCTCATCAAGCCAATCCGGAATTCGCCGGGTGGGTCTGGGCC
ATAGTCGACATCGACCCCGCCGTGATGGACGACACGATCGAACGCGTCAATATCACGCTGCCGCGCCGCATCCTGGCCAG
AATCGATGCGAAGGCGCGCGCCGCCGGCGAAAGCCGATCGGGCTACATCGCGCAGCTGGCCTTGACGCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References