Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 47237..47759 | Replicon | plasmid p.CT30-P3 |
| Accession | NZ_CP032081 | ||
| Organism | Escherichia coli strain CT30 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | D2195_RS25855 | Protein ID | WP_000638823.1 |
| Coordinates | 47237..47518 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | D2195_RS25860 | Protein ID | WP_000121741.1 |
| Coordinates | 47508..47759 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D2195_RS25820 (D2195_27960) | 43386..43706 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| D2195_RS26470 | 43777..44067 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| D2195_RS25830 (D2195_27970) | 44067..44651 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| D2195_RS25835 (D2195_27975) | 44672..45070 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| D2195_RS25840 (D2195_27980) | 45189..45626 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| D2195_RS25845 (D2195_27985) | 45632..46867 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| D2195_RS25850 (D2195_27990) | 46870..47169 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| D2195_RS25855 (D2195_27995) | 47237..47518 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| D2195_RS25860 (D2195_28000) | 47508..47759 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| D2195_RS25865 (D2195_28005) | 47859..48494 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| D2195_RS25870 (D2195_28010) | 48567..48854 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| D2195_RS25875 (D2195_28015) | 48867..49121 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| D2195_RS25880 (D2195_28020) | 49123..49764 | - | 642 | WP_001425343.1 | type IV secretion system protein | - |
| D2195_RS25885 (D2195_28025) | 49770..50765 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| D2195_RS25890 (D2195_28030) | 50769..51026 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| D2195_RS25895 (D2195_28035) | 51023..51325 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| D2195_RS25900 (D2195_28040) | 51306..51563 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| D2195_RS25905 (D2195_28045) | 51596..52042 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| D2195_RS25910 | 52053..52223 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| D2195_RS25915 (D2195_28050) | 52227..52670 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60733 | 60733 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T111058 WP_000638823.1 NZ_CP032081:c47518-47237 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T111058 NZ_CP032081:c47518-47237 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT111058 WP_000121741.1 NZ_CP032081:c47759-47508 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT111058 NZ_CP032081:c47759-47508 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|