Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4217595..4218430 Replicon chromosome
Accession NZ_CP032078
Organism Escherichia coli strain CT30

Toxin (Protein)


Gene name yeeV Uniprot ID F4TIK8
Locus tag D2195_RS20485 Protein ID WP_000854694.1
Coordinates 4217595..4217972 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7S1S5
Locus tag D2195_RS20490 Protein ID WP_065793167.1
Coordinates 4218062..4218430 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D2195_RS20465 (4213103) 4213103..4213282 + 180 Protein_4054 peptidase -
D2195_RS20470 (4213681) 4213681..4215717 - 2037 WP_000417002.1 hypothetical protein -
D2195_RS26345 (4216715) 4216715..4216816 - 102 Protein_4056 hypothetical protein -
D2195_RS20475 (4216901) 4216901..4217098 - 198 WP_000839280.1 DUF957 domain-containing protein -
D2195_RS20480 (4217110) 4217110..4217598 - 489 WP_212408092.1 DUF5983 family protein -
D2195_RS20485 (4217595) 4217595..4217972 - 378 WP_000854694.1 TA system toxin CbtA family protein Toxin
D2195_RS20490 (4218062) 4218062..4218430 - 369 WP_065793167.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
D2195_RS20495 (4218593) 4218593..4218814 - 222 WP_000692303.1 DUF987 domain-containing protein -
D2195_RS20500 (4218877) 4218877..4219353 - 477 WP_001186710.1 RadC family protein -
D2195_RS20505 (4219365) 4219365..4219844 - 480 WP_113837565.1 antirestriction protein -
D2195_RS20510 (4219926) 4219926..4220744 - 819 WP_212408093.1 DUF932 domain-containing protein -
D2195_RS20515 (4220843) 4220843..4221076 - 234 WP_001278287.1 DUF905 family protein -
D2195_RS20520 (4221082) 4221082..4221759 - 678 WP_112042006.1 hypothetical protein -
D2195_RS20525 (4221907) 4221907..4222587 - 681 WP_094122466.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4205372..4231585 26213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14008.02 Da        Isoelectric Point: 7.7293

>T111041 WP_000854694.1 NZ_CP032078:c4217972-4217595 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T111041 NZ_CP032078:c4217972-4217595 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13555.50 Da        Isoelectric Point: 6.6249

>AT111041 WP_065793167.1 NZ_CP032078:c4218430-4218062 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT111041 NZ_CP032078:c4218430-4218062 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1M2F934


Antitoxin

Source ID Structure

References