Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 881526..882361 Replicon chromosome
Accession NZ_CP032078
Organism Escherichia coli strain CT30

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag D2195_RS04280 Protein ID WP_057109034.1
Coordinates 881526..881903 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7W3AJG7
Locus tag D2195_RS04285 Protein ID WP_001389198.1
Coordinates 881993..882361 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D2195_RS04245 (876608) 876608..877213 + 606 WP_001318033.1 type II secretion system minor pseudopilin GspJ -
D2195_RS04250 (877210) 877210..878187 + 978 WP_000633196.1 type II secretion system minor pseudopilin GspK -
D2195_RS04255 (878184) 878184..879362 + 1179 WP_000097200.1 type II secretion system protein GspL -
D2195_RS04260 (879364) 879364..879900 + 537 WP_000942807.1 GspM family type II secretion system protein YghD -
D2195_RS04265 (880180) 880180..881022 - 843 WP_039004748.1 DUF4942 domain-containing protein -
D2195_RS04270 (881107) 881107..881304 - 198 WP_023563519.1 DUF957 domain-containing protein -
D2195_RS04275 (881380) 881380..881529 - 150 Protein_852 DUF5983 family protein -
D2195_RS04280 (881526) 881526..881903 - 378 WP_057109034.1 TA system toxin CbtA family protein Toxin
D2195_RS04285 (881993) 881993..882361 - 369 WP_001389198.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D2195_RS04290 (882441) 882441..882662 - 222 WP_000692287.1 DUF987 domain-containing protein -
D2195_RS04295 (882749) 882749..883225 - 477 WP_001186744.1 RadC family protein -
D2195_RS04300 (883241) 883241..883726 - 486 WP_000213717.1 antirestriction protein -
D2195_RS04305 (883803) 883803..884621 - 819 WP_001175170.1 DUF932 domain-containing protein -
D2195_RS04310 (884711) 884711..884944 - 234 WP_001278288.1 DUF905 family protein -
D2195_RS04315 (884950) 884950..885627 - 678 WP_001097362.1 hypothetical protein -
D2195_RS04320 (885746) 885746..886630 - 885 WP_000010399.1 50S ribosome-binding GTPase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13934.86 Da        Isoelectric Point: 6.8517

>T111022 WP_057109034.1 NZ_CP032078:c881903-881526 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T111022 NZ_CP032078:c881903-881526 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13610.39 Da        Isoelectric Point: 6.3159

>AT111022 WP_001389198.1 NZ_CP032078:c882361-881993 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT111022 NZ_CP032078:c882361-881993 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTTGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7W3AJG7

References