Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4251398..4252323 Replicon chromosome
Accession NZ_CP032073
Organism Escherichia coli strain CT29

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag D2194_RS20615 Protein ID WP_014640052.1
Coordinates 4251398..4251784 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag D2194_RS20620 Protein ID WP_001339382.1
Coordinates 4251814..4252323 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D2194_RS20575 (4247168) 4247168..4247530 + 363 WP_000135682.1 protein YfdP -
D2194_RS20580 (4247596) 4247596..4248420 + 825 WP_000081316.1 DUF2303 family protein -
D2194_RS20585 (4248549) 4248549..4249085 + 537 WP_000008209.1 5'-deoxynucleotidase -
D2194_RS20590 (4249076) 4249076..4249438 + 363 WP_212403157.1 hypothetical protein -
D2194_RS20595 (4249438) 4249438..4250247 + 810 WP_212403159.1 hypothetical protein -
D2194_RS20600 (4250247) 4250247..4250819 + 573 WP_001061348.1 3'-5' exonuclease -
D2194_RS20605 (4250856) 4250856..4251137 + 282 WP_001093917.1 pyocin activator PrtN family protein -
D2194_RS20610 (4251185) 4251185..4251358 - 174 WP_000390072.1 hypothetical protein -
D2194_RS20615 (4251398) 4251398..4251784 - 387 WP_014640052.1 hypothetical protein Toxin
D2194_RS20620 (4251814) 4251814..4252323 - 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
D2194_RS20625 (4252640) 4252640..4252744 - 105 Protein_4078 tRNA-dihydrouridine synthase -
D2194_RS20630 (4253105) 4253105..4253851 - 747 WP_285899689.1 DUF2713 family protein -
D2194_RS23930 (4253846) 4253846..4254097 - 252 Protein_4080 DUF2713 domain-containing protein -
D2194_RS20635 (4254415) 4254415..4254930 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
D2194_RS20640 (4254972) 4254972..4255181 - 210 Protein_4082 CsbD family protein -
D2194_RS20645 (4255297) 4255297..4256622 - 1326 WP_001326646.1 MATE family efflux transporter DinF -
D2194_RS20650 (4256695) 4256695..4257303 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4206023..4257303 51280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T111011 WP_014640052.1 NZ_CP032073:c4251784-4251398 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T111011 NZ_CP032073:c4251784-4251398 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT111011 WP_001339382.1 NZ_CP032073:c4252323-4251814 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT111011 NZ_CP032073:c4252323-4251814 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References