Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1755943..1756778 | Replicon | chromosome |
| Accession | NZ_CP032066 | ||
| Organism | Escherichia coli strain E166 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | F4TIK8 |
| Locus tag | D2J89_RS08415 | Protein ID | WP_000854694.1 |
| Coordinates | 1755943..1756320 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A8S7S1S5 |
| Locus tag | D2J89_RS08420 | Protein ID | WP_065793167.1 |
| Coordinates | 1756410..1756778 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D2J89_RS08380 (1751077) | 1751077..1751370 | - | 294 | WP_001297978.1 | protein YicS | - |
| D2J89_RS08385 (1751592) | 1751592..1752410 | + | 819 | WP_000779405.1 | lipoprotein NlpA | - |
| D2J89_RS08390 (1752414) | 1752414..1753337 | - | 924 | WP_000535959.1 | carboxylate/amino acid/amine transporter | - |
| D2J89_RS08395 (1753504) | 1753504..1754001 | - | 498 | WP_000509808.1 | hypothetical protein | - |
| D2J89_RS08400 (1754597) | 1754597..1755439 | - | 843 | WP_001696593.1 | DUF4942 domain-containing protein | - |
| D2J89_RS08405 (1755524) | 1755524..1755721 | - | 198 | WP_086795284.1 | DUF957 domain-containing protein | - |
| D2J89_RS08410 (1755797) | 1755797..1755946 | - | 150 | Protein_1641 | DUF5983 family protein | - |
| D2J89_RS08415 (1755943) | 1755943..1756320 | - | 378 | WP_000854694.1 | TA system toxin CbtA family protein | Toxin |
| D2J89_RS08420 (1756410) | 1756410..1756778 | - | 369 | WP_065793167.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| D2J89_RS08425 (1756941) | 1756941..1757162 | - | 222 | WP_000692303.1 | DUF987 domain-containing protein | - |
| D2J89_RS08430 (1757225) | 1757225..1757701 | - | 477 | WP_001186773.1 | RadC family protein | - |
| D2J89_RS08435 (1757717) | 1757717..1758196 | - | 480 | WP_021525716.1 | antirestriction protein | - |
| D2J89_RS08440 (1758278) | 1758278..1759096 | - | 819 | WP_001175148.1 | DUF932 domain-containing protein | - |
| D2J89_RS08445 (1759186) | 1759186..1759419 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| D2J89_RS08450 (1759425) | 1759425..1760102 | - | 678 | WP_001097305.1 | hypothetical protein | - |
| D2J89_RS08455 (1760250) | 1760250..1760930 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14008.02 Da Isoelectric Point: 7.7293
>T110957 WP_000854694.1 NZ_CP032066:c1756320-1755943 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T110957 NZ_CP032066:c1756320-1755943 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13555.50 Da Isoelectric Point: 6.6249
>AT110957 WP_065793167.1 NZ_CP032066:c1756778-1756410 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYMAVYPTPETKK
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT110957 NZ_CP032066:c1756778-1756410 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|