Detailed information of TA system TA110950

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3466236..3466889
• Replicon: chromosome
• Accession: NZ_CP032055
• Organism: Acinetobacter baumannii strain A320 (RUH134)

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: A320_RS16460
• Protein ID: WP_000607077.1
• Coordinates: 3466236..3466625 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: A320_RS16465
• Protein ID: WP_001288210.1
• Coordinates: 3466632..3466889 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A320_RS16445	3461354..3463549	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
A320_RS16450	3463737..3464303	-	567	WP_000651538.1	rhombosortase	-
A320_RS16455	3464381..3465466	-	1086	WP_000049106.1	hypothetical protein	-
A320_RS16460	3466236..3466625	-	390	WP_000607077.1	membrane protein	Toxin
A320_RS16465	3466632..3466889	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
A320_RS16470	3467077..3468249	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
A320_RS16475	3468298..3469788	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
A320_RS16480	3469970..3470347	-	378	WP_001216380.1	50S ribosomal protein L17	-
A320_RS16485	3470366..3471373	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T110950 WP_000607077.1 NZ_CP032055:c3466625-3466236 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T110950 NZ_CP032055:c3466625-3466236 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT110950 WP_001288210.1 NZ_CP032055:c3466889-3466632 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT110950 NZ_CP032055:c3466889-3466632 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7