Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2896573..2897224 Replicon chromosome
Accession NZ_CP032055
Organism Acinetobacter baumannii strain A320 (RUH134)

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag A320_RS13795 Protein ID WP_000838146.1
Coordinates 2897042..2897224 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag A320_RS13790 Protein ID WP_000966689.1
Coordinates 2896573..2896977 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A320_RS13775 2891606..2891947 - 342 WP_001281459.1 phage tail protein -
A320_RS13780 2892065..2896030 - 3966 WP_000191304.1 tape measure protein -
A320_RS13785 2896091..2896492 - 402 WP_000720591.1 hypothetical protein -
A320_RS13790 2896573..2896977 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A320_RS13795 2897042..2897224 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
A320_RS13800 2897556..2898089 - 534 WP_001185622.1 hypothetical protein -
A320_RS13805 2898134..2899063 - 930 WP_000094299.1 hypothetical protein -
A320_RS13810 2899171..2899383 - 213 WP_000121166.1 hypothetical protein -
A320_RS13815 2899385..2899783 - 399 WP_001132270.1 hypothetical protein -
A320_RS13820 2899785..2900153 - 369 WP_000539752.1 hypothetical protein -
A320_RS13825 2900125..2900529 - 405 WP_000248323.1 hypothetical protein -
A320_RS13830 2900538..2900906 - 369 WP_000524231.1 hypothetical protein -
A320_RS13835 2900908..2901297 - 390 WP_000008492.1 hypothetical protein -
A320_RS13840 2901302..2901967 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2871784..2927617 55833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T110949 WP_000838146.1 NZ_CP032055:c2897224-2897042 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T110949 NZ_CP032055:c2897224-2897042 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT110949 WP_000966689.1 NZ_CP032055:c2896977-2896573 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT110949 NZ_CP032055:c2896977-2896573 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References