Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 848468..848945 Replicon chromosome
Accession NZ_CP032051
Organism Staphylococcus aureus strain O17

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO17_RS04280 Protein ID WP_000052076.1
Coordinates 848468..848656 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO17_RS04285 Protein ID WP_001059690.1
Coordinates 848685..848945 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO17_RS04245 844198..844719 + 522 WP_000824478.1 hypothetical protein -
SaO17_RS04250 845060..845746 + 687 WP_001641381.1 thermonuclease family protein -
SaO17_RS04255 846103..846303 + 201 WP_001059082.1 cold-shock protein -
SaO17_RS14265 846382..846543 - 162 WP_162887993.1 hypothetical protein -
SaO17_RS04260 846551..846811 + 261 WP_135781824.1 hypothetical protein -
SaO17_RS04265 847059..847277 - 219 WP_000005880.1 hypothetical protein -
SaO17_RS04270 847339..847623 - 285 WP_001004402.1 hypothetical protein -
SaO17_RS04275 847711..848280 - 570 WP_001106650.1 hypothetical protein -
SaO17_RS04280 848468..848656 - 189 WP_000052076.1 hypothetical protein Toxin
SaO17_RS04285 848685..848945 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO17_RS04290 849286..849489 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO17_RS04295 849486..849722 - 237 WP_000368687.1 hypothetical protein -
SaO17_RS04300 849947..850528 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SaO17_RS04305 850601..851218 - 618 WP_118848075.1 LysE/ArgO family amino acid transporter -
SaO17_RS04310 851374..851868 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SaO17_RS04315 852267..852689 - 423 WP_000974462.1 organic hydroperoxide resistance protein -
SaO17_RS04320 852837..853553 + 717 WP_000150023.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T110936 WP_000052076.1 NZ_CP032051:c848656-848468 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T110936 NZ_CP032051:c848656-848468 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT110936 WP_001059690.1 NZ_CP032051:c848945-848685 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT110936 NZ_CP032051:c848945-848685 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References