Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 323239..324042 Replicon chromosome
Accession NZ_CP032051
Organism Staphylococcus aureus strain O17

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag SaO17_RS01465 Protein ID WP_118848034.1
Coordinates 323239..323700 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag SaO17_RS01470 Protein ID WP_001573842.1
Coordinates 323713..324042 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO17_RS01440 320185..321390 - 1206 WP_065316550.1 site-specific integrase -
SaO17_RS01445 321518..322132 + 615 WP_065316551.1 ATPase -
SaO17_RS01450 322129..322275 - 147 WP_001013104.1 hypothetical protein -
SaO17_RS01455 322364..322759 - 396 WP_001558060.1 hypothetical protein -
SaO17_RS01460 322787..323221 - 435 WP_118848033.1 hypothetical protein -
SaO17_RS01465 323239..323700 - 462 WP_118848034.1 toxin Toxin
SaO17_RS01470 323713..324042 - 330 WP_001573842.1 helix-turn-helix domain-containing protein Antitoxin
SaO17_RS01475 324234..324479 + 246 WP_065316554.1 helix-turn-helix domain-containing protein -
SaO17_RS14255 324493..324669 + 177 WP_015994739.1 hypothetical protein -
SaO17_RS01480 324666..324896 - 231 WP_000549548.1 hypothetical protein -
SaO17_RS01485 324951..325238 + 288 WP_065316727.1 hypothetical protein -
SaO17_RS01490 325186..325428 - 243 WP_000498529.1 hypothetical protein -
SaO17_RS01495 325488..325703 + 216 WP_001097552.1 hypothetical protein -
SaO17_RS01500 325728..325991 + 264 WP_118848035.1 helix-turn-helix domain-containing protein -
SaO17_RS01505 326004..326171 + 168 WP_118848036.1 DUF1270 domain-containing protein -
SaO17_RS01510 326172..326492 + 321 WP_000219664.1 hypothetical protein -
SaO17_RS01515 326586..326939 + 354 WP_118848037.1 DUF1108 family protein -
SaO17_RS01520 326939..327295 + 357 WP_015977669.1 hypothetical protein -
SaO17_RS01525 327292..328533 + 1242 WP_118848038.1 AAA family ATPase -
SaO17_RS01530 328530..328745 + 216 WP_001024404.1 hypothetical protein -
SaO17_RS01535 328748..328969 + 222 WP_001123688.1 DUF3269 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - geh 315628..358814 43186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17899.27 Da        Isoelectric Point: 4.6696

>T110932 WP_118848034.1 NZ_CP032051:c323700-323239 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILLEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLGVFKYKEI

Download         Length: 462 bp

>T110932 NZ_CP032051:c323700-323239 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTAGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAGTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCAGTCCCGTTACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAATTTGTACGAGTT
GTCAGAGTATCTGCAGTTGAGTGAATCATACATACTAGAAGCTATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACGTTTGAGCCGTTGGGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12730.33 Da        Isoelectric Point: 6.4836

>AT110932 WP_001573842.1 NZ_CP032051:c324042-323713 [Staphylococcus aureus]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT110932 NZ_CP032051:c324042-323713 [Staphylococcus aureus]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCTCTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCATTTAGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAA
ACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References