Detailed information of TA system TA110926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 568551..569772
• Replicon: chromosome
• Accession: NZ_CP032011
• Organism: Burkholderia cepacia strain 39628

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2FUP4
• Locus tag: C7S14_RS25210
• Protein ID: WP_021162781.1
• Coordinates: 569191..569772 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: C7S14_RS25205
• Protein ID: WP_192389676.1
• Coordinates: 568551..569108 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7S14_RS25180	563947..564678	-	732	WP_006498851.1	ribonuclease T2	-
C7S14_RS25185	564909..565298	+	390	WP_192389673.1	OsmC family protein	-
C7S14_RS25190	565380..565958	-	579	WP_021162777.1	hypothetical protein	-
C7S14_RS25195	566055..567458	-	1404	WP_192389674.1	DUF308 domain-containing protein	-
C7S14_RS25200	567819..568496	+	678	WP_192389675.1	hypothetical protein	-
C7S14_RS25205	568551..569108	+	558	WP_192389676.1	helix-turn-helix domain-containing protein	Antitoxin
C7S14_RS25210	569191..569772	+	582	WP_021162781.1	HD domain-containing protein	Toxin
C7S14_RS25215	569828..570556	+	729	WP_059812766.1	class I SAM-dependent methyltransferase	-
C7S14_RS25220	570844..572037	+	1194	WP_021162784.1	macrolide transporter subunit MacA	-
C7S14_RS25225	572040..574100	+	2061	WP_059812764.1	MacB family efflux pump subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-172)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21256.86 Da
• Isoelectric Point: 5.2812

>T110926 WP_021162781.1 NZ_CP032011:569191-569772 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPAQRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGRNPPGFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDASGQHA

Nucleotide

• Length: 582 bp

>T110926 NZ_CP032011:569191-569772 [Burkholderia cepacia]
ATGAATCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGACGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCGCAGCGCGACGAGATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCCGCAATCCGCCCGGTTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGAGCGGGCAGCACGCGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20058.07 Da
• Isoelectric Point: 11.1002

>AT110926 WP_192389676.1 NZ_CP032011:568551-569108 [Burkholderia cepacia]
MSASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERATAERLLAARLDSAGDRALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPAIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT110926 NZ_CP032011:568551-569108 [Burkholderia cepacia]
ATGTCTGCCTCACCGCTACACACGCCGCCACTCGGCCCGCAACTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAACAGAG
CCACGCGGCGGAACTGTTCGGCGTGGCGCAGTCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGATCGCGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCATCGGCTGCTCGCCTGTTCGCCTGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGCAATCGTCCGCATGGAAACCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGTCGGCCGCGCGGCTCGTGGAAACGCTGTAG

Structures

Toxin

• AlphaFold DB: U2FUP4