Detailed information of TA system TA110925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 327132..327787
• Replicon: chromosome
• Accession: NZ_CP032011
• Organism: Burkholderia cepacia strain 39628

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C7S14_RS24225
• Protein ID: WP_192389606.1
• Coordinates: 327132..327551 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: C7S14_RS24230
• Protein ID: WP_021158161.1
• Coordinates: 327548..327787 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7S14_RS24200	322354..323148	+	795	WP_192389605.1	AraC family transcriptional regulator	-
C7S14_RS24205	323543..324505	+	963	WP_192390238.1	DMT family transporter	-
C7S14_RS24210	324691..325239	+	549	WP_059619276.1	hypothetical protein	-
C7S14_RS24215	325333..325467	-	135	WP_021158165.1	entericidin A/B family lipoprotein	-
C7S14_RS24220	325701..326996	+	1296	WP_021158163.1	aspartate carbamoyltransferase	-
C7S14_RS24225	327132..327551	-	420	WP_192389606.1	type II toxin-antitoxin system VapC family toxin	Toxin
C7S14_RS24230	327548..327787	-	240	WP_021158161.1	antitoxin VapB	Antitoxin
C7S14_RS24235	328098..330344	+	2247	WP_059492139.1	TonB-dependent siderophore receptor	-
C7S14_RS24240	330348..331115	+	768	WP_192389607.1	sel1 repeat family protein	-
C7S14_RS24245	331112..331795	+	684	WP_192389608.1	Fe2+-dependent dioxygenase	-
C7S14_RS24250	331883..332122	+	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C7S14_RS24255	332119..332514	+	396	WP_042973908.1	type II toxin-antitoxin system VapC family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15113.43 Da
• Isoelectric Point: 5.2171

>T110925 WP_192389606.1 NZ_CP032011:c327551-327132 [Burkholderia cepacia]
MILVDTNVISEPLRGEPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T110925 NZ_CP032011:c327551-327132 [Burkholderia cepacia]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGAGGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGATGTCACGCCGTTCGAGGCAATGGGAATTCGCGTAA
TCGACCCGTGGGCGCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT110925 WP_021158161.1 NZ_CP032011:c327787-327548 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT110925 NZ_CP032011:c327787-327548 [Burkholderia cepacia]
ATGCCGGTGATCACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCAGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGATCCGATGAGCTTCGAATGA

Structures

Antitoxin

• AlphaFold DB: U2HMP5