Detailed information of TA system TA110923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3307732..3308369
• Replicon: chromosome
• Accession: NZ_CP032009
• Organism: Burkholderia cepacia strain 39628

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2FRJ0
• Locus tag: C7S14_RS15270
• Protein ID: WP_021164186.1
• Coordinates: 3307968..3308369 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: C7S14_RS15265
• Protein ID: WP_042978332.1
• Coordinates: 3307732..3307968 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7S14_RS15250	3303327..3304358	+	1032	WP_042978041.1	helix-turn-helix domain-containing protein	-
C7S14_RS15255	3304506..3305618	-	1113	WP_192386766.1	ADP-heptose--LPS heptosyltransferase	-
C7S14_RS15260	3305615..3307318	-	1704	WP_059678233.1	thiamine pyrophosphate-binding protein	-
C7S14_RS15265	3307732..3307968	+	237	WP_042978332.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C7S14_RS15270	3307968..3308369	+	402	WP_021164186.1	type II toxin-antitoxin system VapC family toxin	Toxin
C7S14_RS15275	3308437..3309825	-	1389	WP_021164187.1	L-serine ammonia-lyase	-
C7S14_RS15280	3309856..3310989	-	1134	WP_021164188.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15033.14 Da
• Isoelectric Point: 5.2050

>T110923 WP_021164186.1 NZ_CP032009:3307968-3308369 [Burkholderia cepacia]
MPRYMLDTNMCIYLMKHQPEQVAKRFAQCYTGDVVMSAITYAELEYGVAACANAVRERRNLADLIEDIPVAPFDAAAAQA
YGPVREATRERKRDHLDKLIAAHAVSLDVVLVTNNERDFASYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T110923 NZ_CP032009:3307968-3308369 [Burkholderia cepacia]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATTTGATGAAGCATCAGCCGGAACAGGTCGCGAAACGATTTGC
CCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATTACCTACGCCGAGCTCGAATACGGCGTGGCCGCGTGTGCGAATG
CGGTCCGGGAGCGCCGCAACCTTGCCGACCTGATCGAGGATATTCCGGTTGCGCCGTTCGACGCGGCGGCCGCGCAAGCG
TACGGCCCTGTTCGCGAAGCGACCCGCGAGCGGAAGAGGGATCATCTCGACAAACTGATCGCGGCGCACGCGGTGTCGCT
CGACGTCGTGCTCGTGACCAACAACGAGCGGGATTTCGCGAGTTACCCGGGGTTGCGGCTGGAGAACTGGCTGAACGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8926.06 Da
• Isoelectric Point: 5.1651

>AT110923 WP_042978332.1 NZ_CP032009:3307732-3307968 [Burkholderia cepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPVRRPLAGVLEKFAKFAPDFMAEGRGDQEQADREGL

Nucleotide

• Length: 237 bp

>AT110923 NZ_CP032009:3307732-3307968 [Burkholderia cepacia]
ATGCATACCACGAGGGTGTTCCGGAACGGCAACTCGCAGGCCGTACGGATTCCGGCGGATCTTGCCTACGAGCGCAGCGA
TATCGAGCTCGAAATCGAACGGATCGGCGACGAAATCCGTATTCGTCCCGTGCGACGGCCGTTGGCTGGCGTGCTCGAGA
AGTTCGCGAAATTCGCACCGGATTTCATGGCTGAAGGGCGTGGCGACCAGGAGCAGGCCGACCGCGAGGGTTTGTGA

Structures

Toxin

• AlphaFold DB: U2FRJ0