110921

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 376..935 Replicon plasmid pAhaem11616a
Accession NZ_CP032008
Organism Acinetobacter haemolyticus strain 11616

Toxin (Protein)


Gene name parE Uniprot ID A0A845PNQ4
Locus tag Ahae11616_RS17355 Protein ID WP_017394606.1
Coordinates 376..666 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9GV48
Locus tag Ahae11616_RS17360 Protein ID WP_005086675.1
Coordinates 654..935 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ahae11616_RS17350 1..5017 - 5017 WP_005086676.1 replication initiation protein -
Ahae11616_RS17355 376..666 - 291 WP_017394606.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Ahae11616_RS17360 654..935 - 282 WP_005086675.1 hypothetical protein Antitoxin
Ahae11616_RS17365 989..1267 - 279 WP_005086673.1 hypothetical protein -
Ahae11616_RS17370 1332..3152 - 1821 WP_005086671.1 relaxase/mobilization nuclease domain-containing protein -
Ahae11616_RS17375 3142..3504 - 363 WP_017394605.1 MobC family plasmid mobilization relaxosome protein -
Ahae11616_RS17380 3971..4183 - 213 WP_005086682.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..5017 5017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11005.68 Da        Isoelectric Point: 9.4389

>T110921 WP_017394606.1 NZ_CP032008:c666-376 [Acinetobacter haemolyticus]
MPQVILTRNALNDLSRLKVFLQTKNPEAAKEAVITIRSHLKELATTPLAHVPDDERPDFRILIIPFGSSGYKAWYRYKTG
EDVVIVSIKHQREDAY

Download         Length: 291 bp

>T110921 NZ_CP032008:c666-376 [Acinetobacter haemolyticus]
ATGCCACAAGTAATTTTAACCAGAAACGCCCTTAATGATTTGAGCCGATTAAAGGTGTTTTTGCAGACAAAGAACCCAGA
AGCGGCTAAGGAAGCGGTTATAACTATCCGATCTCACCTCAAGGAATTAGCCACTACACCATTGGCTCATGTACCTGACG
ATGAGCGACCAGATTTTAGGATATTGATAATCCCTTTTGGTTCAAGTGGATACAAGGCTTGGTATCGTTACAAAACTGGT
GAGGATGTTGTGATAGTCTCAATCAAGCATCAACGAGAAGATGCGTATTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10539.79 Da        Isoelectric Point: 4.9348

>AT110921 WP_005086675.1 NZ_CP032008:c935-654 [Acinetobacter haemolyticus]
MSTIALSIKLDSSYKDRLSRLATTKKRTAHALAKAAITSFIEQEERIEAERREAIASYEDYLETGLHVTLAEADEWLESW
GTDNEKDAPLCHK

Download         Length: 282 bp

>AT110921 NZ_CP032008:c935-654 [Acinetobacter haemolyticus]
ATGTCCACCATAGCACTGTCCATCAAGCTTGATTCAAGCTATAAAGACCGTTTAAGCCGTTTAGCCACCACCAAAAAGCG
TACAGCACACGCATTGGCAAAGGCTGCAATCACTAGTTTTATCGAGCAAGAGGAGCGCATTGAGGCAGAGCGGAGAGAAG
CTATAGCCTCGTATGAAGATTATCTGGAAACAGGGCTGCATGTAACTCTAGCAGAAGCGGATGAGTGGCTGGAGAGTTGG
GGAACTGACAATGAGAAAGATGCACCCCTATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A845PNQ4

Antitoxin

Source ID Structure
AlphaFold DB N9GV48

References