110917

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1658714..1659846 Replicon chromosome
Accession NZ_CP032002
Organism Acinetobacter haemolyticus strain 11616

Toxin (Protein)


Gene name - Uniprot ID C0VPL6
Locus tag Ahae11616_RS08050 Protein ID WP_004639220.1
Coordinates 1658714..1659478 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag Ahae11616_RS08055 Protein ID WP_004639219.1
Coordinates 1659475..1659846 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ahae11616_RS08025 1654622..1655479 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
Ahae11616_RS08030 1655571..1656860 + 1290 WP_004639224.1 phosphopyruvate hydratase -
Ahae11616_RS08035 1656990..1657355 + 366 WP_004639223.1 cell division protein FtsB -
Ahae11616_RS08040 1657345..1658052 + 708 WP_004639222.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
Ahae11616_RS08045 1658179..1658655 + 477 WP_005090442.1 hypothetical protein -
Ahae11616_RS08050 1658714..1659478 - 765 WP_004639220.1 RES family NAD+ phosphorylase Toxin
Ahae11616_RS08055 1659475..1659846 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
Ahae11616_RS08060 1660062..1660475 + 414 WP_005080585.1 YeeE/YedE family protein -
Ahae11616_RS08065 1660477..1660890 + 414 WP_005090445.1 YeeE/YedE family protein -
Ahae11616_RS08070 1660905..1661777 + 873 WP_005080588.1 MBL fold metallo-hydrolase -
Ahae11616_RS08075 1661946..1662557 + 612 WP_160124270.1 phosphoglycerate mutase family protein -
Ahae11616_RS08080 1662610..1663775 + 1166 WP_100223926.1 IS3 family transposase -
Ahae11616_RS08090 1664061..1664321 + 261 WP_005080592.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29094.01 Da        Isoelectric Point: 5.5775

>T110917 WP_004639220.1 NZ_CP032002:c1659478-1658714 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWYSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGVEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T110917 NZ_CP032002:c1659478-1658714 [Acinetobacter haemolyticus]
ATGACCGCAATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGGTCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGTACTCAATGGATGGTGCACCAAAGAAAAAAACGATACGCACTGAGCATA
CTTTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGTACAGCAATGCGGAATGAAGGAGTTGAGATCTTTGAGTATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAGAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT110917 WP_004639219.1 NZ_CP032002:c1659846-1659475 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT110917 NZ_CP032002:c1659846-1659475 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTACTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTAGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A372MQ11

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References