Detailed information of TA system TA110915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1299547..1300057
• Replicon: chromosome
• Accession: NZ_CP032002
• Organism: Acinetobacter haemolyticus strain 11616

Toxin (Protein)

• Gene name: relB
• Uniprot ID: N8PSJ1
• Locus tag: Ahae11616_RS06245
• Protein ID: WP_004671840.1
• Coordinates: 1299547..1299810 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Ahae11616_RS06250
• Protein ID: WP_125317037.1
• Coordinates: 1299794..1300057 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ahae11616_RS06230	1295218..1296495	-	1278	WP_017395975.1	site-specific integrase	-
Ahae11616_RS06235	1296830..1298038	+	1209	WP_125317005.1	integrase arm-type DNA-binding domain-containing protein	-
Ahae11616_RS06240	1298124..1299176	-	1053	WP_125317036.1	hypothetical protein	-
Ahae11616_RS06245	1299547..1299810	-	264	WP_004671840.1	Txe/YoeB family addiction module toxin	Toxin
Ahae11616_RS06250	1299794..1300057	-	264	WP_125317037.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Ahae11616_RS06255	1300474..1300740	-	267	WP_125317006.1	AlpA family phage regulatory protein	-
Ahae11616_RS06260	1300834..1301874	-	1041	WP_160124242.1	hypothetical protein	-
Ahae11616_RS06265	1302128..1302511	+	384	WP_001055585.1	IS66 family insertion sequence hypothetical protein	-
Ahae11616_RS06270	1302508..1302843	+	336	WP_000618091.1	IS66 family insertion sequence element accessory protein TnpB	-
Ahae11616_RS06275	1302918..1304501	+	1584	WP_005080957.1	IS66-like element ISAba25 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1247902..1316471	68569

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10358.93 Da
• Isoelectric Point: 9.0098

>T110915 WP_004671840.1 NZ_CP032002:c1299810-1299547 [Acinetobacter haemolyticus]
MKRKTSFTPTAWEDYVYWQSQDKKTLKRINTLIKECLRTPFEGIGKPEPLLGDLAGFWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T110915 NZ_CP032002:c1299810-1299547 [Acinetobacter haemolyticus]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAAGATTATGTGTACTGGCAAAGCCAAGACAAAAAAACGCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACTCCCTTTGAAGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTTTGGAGCAGGCGAATAGATGAGAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCAATCACAATAATT
TCTTGTCGTTATCACTATGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9882.05 Da
• Isoelectric Point: 4.3176

>AT110915 WP_125317037.1 NZ_CP032002:c1300057-1299794 [Acinetobacter haemolyticus]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLYLMSSPSNATHLAQSIAELRASKTIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT110915 NZ_CP032002:c1300057-1299794 [Acinetobacter haemolyticus]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTTATTGATGATTCAGATGTTGC
AGTAATTACGAGGAAAGAAGGTCAACATGCCGTTGTAATGGGACAAGACTATTACAACAGTATAATGGAAACATTGTACC
TCATGTCTTCTCCAAGTAACGCAACACACTTAGCGCAGTCAATTGCAGAGTTACGAGCGTCTAAAACAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A3Q8XJ07